distribution

4-Hydroxyantipyrine 是在氨基比林的氧化脱氨过程中形成的。

UK-101 是一种强效且具有选择性的免疫蛋白酶体 LMP2 的抑制剂 ，对 β1i (LMP2) 、 β1c (LMP2) 和 β5 (LMP2) 具有抑制作用，IC50 为 104nM 、15 μM 和 1 μM 。UK-101 对 β1i 的亲和力比β1c 和 β5 亚基分布高的 144 倍和 10 倍。UK-101 可诱导细胞凋亡且可用于研究前列腺癌的相关疾病。

Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。

7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。

Recilisib, also known as ON 01210.Na, is a radioprotectant, which modifys cell cycle distribution patterns in cancer cells subjected to radiation therapy, and it has been identified as a potential candidate for radiation protection studies. It appears tha

Anguizole, a small molecule, effectively inhibits Hepatitis C Virus (HCV) replication by modifying the subcellular distribution of NS4B. It demonstrates its potency with an IC50 value, highlighting its specific target action against HCV.

Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and

Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he

Ferroptosis-IN-12（Cpd-A1）作为一种ferroptosis抑制剂，能有效抑制Erastin处理的小鼠肾小管上皮细胞（mTECs）中的ferroptosis。该化合物在缺血 再灌注（I R）或盲肠结扎穿刺（CLP）诱导的急性肾损伤（AKI）小鼠模型中显示出剂量依赖性的肾功能改善效果，能减轻肾小管损伤并消除炎症。在药代动力学的研究中，Ferroptosis-IN-12展示了良好的血浆稳定性和在肾脏组织中的高分布性。此外，Ferroptosis-IN-12在急性肾损伤（AKI）研究领域显示出应用潜力。

1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p 22:6-PE) 为一种通过质谱成像技术在大鼠脑组织中确认的独特结构脂质，此方法可准确识别其不同脂肪酸链的异构体及其分布。

PF-07265028 是一种HPK1抑制剂，其IC50为17 nM。在进行了体内药代动力学研究后，PF-07265028在小鼠和猴子体内表现出适中的清除率、终端半衰期、分布容积及口服生物利用度。PF-07265028定位、结合并抑制Hpk1的活性，进而阻断Hpk1介导的信号传导途径，防止Hpk1介导的免疫抑制，包括阻止T细胞受体（TCR）信号的抑制、效应T细胞的抑制、破坏异常的细胞因子表达，并消除免疫抑制性肿瘤微环境（TME）。这可能激活针对肿瘤细胞的细胞毒性T淋巴细胞（CTL）介导的免疫反应。Hpk1主要在造血细胞中表达，是TCR信号和T、B细胞激活的负向调节因子。

Telinavir (SC-52151) 是一种高效且专一的HIV蛋白酶 (HIV protease) 抑制剂。它抑制HIV-1、HIV-2和猿猴免疫缺陷病毒的淋巴嗜性、单核嗜性菌株及野生株，EC50值为26 ng/mL (43 nM)。Telinavir 在人血浆中的蛋白结合率很高，而在红细胞的分配率较低。

Flt-3L-Ig (hum/hum) (hFlt3L) 是一种Flt3激活剂。Flt-3L-Ig (hum/hum) 能提高BRGSF-CBC小鼠中OKT3诱导的髓系细胞和树突状细胞的炎性细胞因子释放，并增加人类免疫细胞的数量和分布，引发细胞因子释放综合征 (CRS)。

Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection.

WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α-

Arbaclofen placarbil( XP19986) is a GABA(B) receptor agonist.Arbaclofen Placarbil is a novel R-baclofen prodrug with improved absorption, distribution, metabolism, and elimination properties compared to R-baclofen. And it can reduce postprandial reflux in

HDEL intracellular distribution is characteristic of plant endoplasmic reticulum (ER).

MIP-1095 I-123, as a radiotracer, is under investigation in clinical trial NCT00712829 (Evaluating the Safety, Pharmacokinetics, Tissue Distribution, Metabolism and Dosimetry of Two Prostate Cancer Imaging Agents).

PROTAC_ERRalpha is a proteolysis targeting chimeras (PROTAC) which provides broad tissue distribution and knockdown of the targeted ERRalpha protein in tumor xenografts.

Teduglutide acetate 是一种 GLP-2 类似物，可使小肠黏膜肥大。它通过改变 claudin-10 的分布部分恢复小肠上皮功能，促进钠再循环以进行钠耦合葡萄糖转运和水吸收。

Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 μM. This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.

Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.[3] Reference：[1]. Neeper, M., Schmidt, A.M., Brett, J., et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. The Journal of Biological Chemisty 267(21), 14998-15004 (1992).[2]. Brett, J., Schmidt, A.M., Yan, S.D., et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. American Journal of Pathology 143(6), 1699-1712 (1993).[3]. Miyata, T., Ueda, Y., Horie, K., et al. Renal catabolism of advanced glycation end products: The fate of pentosidine. Kidney International 53, 416-422 (1998).

Resolvin D1 is produced physiologically from the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase . It reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with an EC50 value of ~30 nM. RvD1 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.

Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. It evokes diverse anti-inflammatory effects which may mediate the resolution of inflammation. RvD2 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.