dextromethorphan

Dextromethorphan 是一种非竞争性 NMDA 受体拮抗剂和 sigma-1激动剂，于 1958 年获得 FDA 批准用作止咳药。

Dextromethorphan-d3 是 Dextromethorphan 的氘代化合物。

Dextromethorphan-d3 HBr 是 Dextromethorphan HBr 的氘代化合物。Dextromethorphan HBr 的 CAS 号为 125-69-9。

Dextrorphan-d3 Tartrate 是 Dextrorphan Tartrate 的氘代化合物。Dextrorphan Tartrate 的 CAS 号为 77-07-6。Dextrorphan tartrate 是一种非竞争性 NMDA 谷氨酸受体拮抗剂。

Dextrallorphan (DXA) is an chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan was found to have a half maximal inhibitory concentration (IC50) for binding to the pituitary and brain receptor of 10,000 ± 1000 nM and 10,000 ± 1500 nM, respectively. While its stereoisomer, levallorphan, had a 10,000 times more potent dose, thus proving that binding to these receptors is stereospecific.