d-12

Banoxantrone D12 (AQ4N D12) is the deuterium-labeled form of Banoxantrone, a bioreductive agent that can be metabolically converted to AQ4, a stable compound with DNA affinity and topoisomerase II inhibition properties.

Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor.

Banoxantrone D12 (AQ4N D12) dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.

D-Glucose-d12-12是D-Glucose的氘代物。D-Glucose (Glucose) 是一种单糖，是重要的生物碳水化合物，常用于作为甜味剂。作为一般代谢中的关键成分，它是与细胞代谢状态和生物及非生物应激反应相关的关键信号分子。

3-Hydroxyoctanoic Acid-d12 是 3-Hydroxyoctanoic Acid 的氘代物。

Vancomycin-d12 TFA 是 Vancomycin TFA 的氘代化合物。Vancomycin TFA 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素，用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。

Adenosine monophosphate-d12 (AMP-d12) dilithium 是一种氘代标记的Adenosine monophosphate。Adenosine monophosphate 是腺苷 A1 受体 (adenosine A1 receptor) 的激动剂，对HSV-1和HSV-2表现出显著的抗病毒活性，同时也是调节能量稳态和信号转导的重要细胞代谢物。

Benzyl benzoate-d12是Benzyl benzoate的氘代物。Benzyl benzoate (Benzoic acid benzyl ester) 在化妆品中用作香料成分，并用于研究与疥疮和蠕形螨相关的炎症性皮肤病。

1,4-Diazabicyclo[2.2.2]octane-d12 是 1,4-Diazabicyclo[2.2.2]octane 的氘代物。

2'-Deoxyadenosine-5'-monophosphate-d12dilithium 是氘代标记的 2'-Deoxyadenosine-5'-monophosphate。2'-Deoxyadenosine 5'-monophosphate 是 DNA 中的脱氧核糖核苷酸，也是核酸 AMP 的衍生物。该化合物可用于研究 DNA 合成和 DNA 损伤过程中涉及腺苷的相互作用。

Ethylenediaminetetraacetic acid-d12是Ethylenediaminetetraacetic acid的氘代物。Ethylenediaminetetraacetic acid (EDTA) 是一种金属螯合剂，可以结合包括钙在内的二价和三价金属阳离子，具有抗高钙血症和抗凝血活性。它能够减少金属离子催化的蛋白质氧化损伤，维持蛋白质纯化过程中的还原环境，因此常用于蛋白质的纯化和储存。同时，EDTA还可以减少二硫键的形成。

4-Methylpentanoic acid-d12是4-Methylpentanoic acid的氘代衍生物。4-Methylpentanoic acid（Isocaproic Acid）是一种短链脂肪酸（SCFA）。

Adenosine monophosphate-15N5,d12 (AMP-15N5,d12) dilithium 是一种氘代和15N标记的Adenosine monophosphate。它作为腺苷A1受体 (adenosine A1 receptor) 的激动剂，对HSV-1和HSV-2显示出显著的抗病毒活性。此外，Adenosine monophosphate 是调节能量稳态和信号转导的关键细胞代谢物。

Cytidine 5′-monophosphate-d12 (5'-Cytidylic acid-d12 dilithium; 5'-CMP-d12) dilithium 是氘代标记的 Cytidine 5'-monophosphate。Cytidine 5'-monophosphate (5'-Cytidylic acid) 是一种由胞嘧啶、戊糖核糖和磷酸基团组成的核苷酸，用作 RNA 的单体。

Cyclosporin A-d12 (Cyclosporine A-d12) 是氘代标记的 Cyclosporin A。Cyclosporin A (Cyclosporine A) 是一种能够抑制免疫反应的免疫抑制剂，能与亲环素结合，并以 IC50 值 7 nM 抑制 protein phosphatase 2B (PP2B/calcineurin) 的活性。此外，Cyclosporin A 还能抑制 CD11a/CD18 粘附分子。

Tetramethylpyrazine-d12 是 Tetramethylpyrazine 的氘代化合物。Tetramethylpyrazine 的 CAS 号为 1124-11-4。Tetramethylpyrazine 是从Ligusticum wallichii中提取的一种烷基吡嗪，常在薯条、面包、茶、乳制品、豆制品等食物中作为香精。它对大鼠具有潜在的抗神经和抗炎活性。

Chrysene-d12 是 Chrysene 的氘代化合物。Chrysene 的 CAS 号为 218-01-9。Chrysene 是高分子量 (HMW) 多环芳烃，有极强的顽固性和致癌性。

Benzo[k]fluoranthene-d12 是 Benzo[k]fluoranthene 的氘代化合物。Benzo[k]fluoranthene 的 CAS 号为 207-08-9。

Perylene-d12 是 Perylene 的氘代化合物。Perylene 的 CAS 号为 198-55-0。

Chrysene-d12 (Standard) 是 Chrysene-d12 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Chrysene-d12 是 Chrysene 的氘代化合物。Chrysene 的 CAS 号为 218-01-9。Chrysene 是高分子量 (HMW) 多环芳烃，有极强的顽固性和致癌性。

Perylene-d12 (Standard) 是 Perylene-d12 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Perylene-d12 是 Perylene 的氘代化合物。Perylene 的 CAS 号为 198-55-0。

WNK-IN-12 is an effective, selective, and orally active WNK1 kinase inhibitor.

Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Aliment.31(4-6)607-615(1977) 2.Chen, B., Li, D., Li, M., et al.Induction of mitochondria-mediated apoptosis and PI3K/Akt/mTOR-mediated autophagy by aflatoxin B2 in hepatocytes of broilersOncotarget7(51)84989-84998(2016) 3.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogsCancer Res.31(12)1936-1942(1971)

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current.3 Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively.4,5 In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid or dihydroxyphenyl acetic acid , and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson's disease.6 Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy. |1. Masuda, Y., Ishizaki, M., and Shimizu, M. Zonisamide: Pharmacology and clinical efficacy in epilepsy. CNS Drug Rev. 4(4), 341-360 (1998).|2. Rock, D.M., Macdonald, R.L., and Taylor, C.P. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Res. 3(2), 138-143 (1989).|3. Suzuki, S., Kawakami, K., Nishimura, S., et al. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex. Epilepsy Res. 12(1), 21-27 (1992).|4. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pylori. Bioorg. Med. Chem. Lett. 16(8), 2182-2188 (2006).|5. De Simone, G., Di Fiore, A., Menchise, V., et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies. Bioorg. Med. Chem. Lett. 15(9), 2315-2320 (2005).|6. Yabe, H., Choudhury, M.E., Kubo, M., et al. Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP. J. Pharmacol. Sci. 110(1), 64-68 (2009).