d-12

Banoxantrone D12 (AQ4N D12) is the deuterium-labeled form of Banoxantrone, a bioreductive agent that can be metabolically converted to AQ4, a stable compound with DNA affinity and topoisomerase II inhibition properties.

Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor.

Banoxantrone D12 (AQ4N D12) dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.

Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) 是一种IgG1类人源单克隆抗体，与MERS-CoV Spike蛋白的二聚体结构中的受体结合域(RBD)上的DPP4相互作用区直接结合，实现通过阻断受体结合的方式达到中和效果。

3-Keto Sphinganine (d12:0) is a short-chain analog of 3-keto sphinganine (d18:0), which typically possesses a C18 chain length. The latter is a lyso-sphingolipid synthesized through the condensation of L-serine and palmitoyl-CoA mediated by the enzyme serine palmitoyl transferase (SPT). A deficiency in Vitamin K deactivates SPT, leading to a reduced synthesis of 3-keto sphinganine among other sphingolipids. [Matreya, LLC. Catalog No. 1893]

Vancomycin-d12 TFA 是 Vancomycin TFA 的氘代化合物。Vancomycin TFA 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素，用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。

Tetramethylpyrazine-d12 是 Tetramethylpyrazine 的氘代化合物。Tetramethylpyrazine 的 CAS 号为 1124-11-4。Tetramethylpyrazine 是从Ligusticum wallichii中提取的一种烷基吡嗪，常在薯条、面包、茶、乳制品、豆制品等食物中作为香精。它对大鼠具有潜在的抗神经和抗炎活性。

Chrysene-d12 是 Chrysene 的氘代化合物。Chrysene 的 CAS 号为 218-01-9。Chrysene 是高分子量 (HMW) 多环芳烃，有极强的顽固性和致癌性。

Benzo[k]fluoranthene-d12 是 Benzo[k]fluoranthene 的氘代化合物。Benzo[k]fluoranthene 的 CAS 号为 207-08-9。

Perylene-d12 是 Perylene 的氘代化合物。Perylene 的 CAS 号为 198-55-0。

C12-Sphingosine (Sphingosine (d12:1)) 是一种具有 12 个碳原子的鞘氨醇同系物，诱导丝氨酸棕榈酰转移酶活性以时间和浓度依赖性方式降低。

ZED-1227 (TAK-227) 是一种具有口服活性、选择性和高效性的转谷氨酰胺酶 2 (TG2) 抑制剂，具有抗癌活性，能阻塞炎症诱导的 TG2 表达和激活，可用于治疗乳糜泻。

ERD-1233，一种雌激素受体 (estrogen receptor) PROTAC降解剂，具有高效性和可口服的特点，其DC50值仅为0.9 nM。该化合物在ER+乳腺癌的研究中展示出关键作用。

IRAK4 ligand-12 是一种PROTAC靶蛋白配体 (Ligand for Target Protein for PROTAC)，可用于合成KTX-951。

SMARCA2 ligand-12 是一种PROTAC靶蛋白配体 (Ligand for Target Protein for PROTAC)，用于合成PROTAC SMARCA2 degrader-25。

ERD-12310A 是一款针对雌激素受体 α (ERα)的PROTAC，具有47 pM的ED50值，并且具备口服活性。

SMARCA2 ligand-12-3-methylazetidin 是一种靶蛋白配体-连接子结合物 (target protein ligand-linker conjugate)，其结合了SMARCA2的配体和PROTAC连接子，可以招募E3连接酶。SMARCA2 ligand-12-3-methylazetidin 可用于合成PROTAC SMARCA2 degrader-25。

CDD-1281 是一种高效且选择性的 BMPR2 激酶抑制剂，IC50 为 1.2 nM，有效抑制 BMP 介导的基因表达。

CRBN ligand-12 (Compound 9) 是一种CRBN 型 E3 泛素连接酶配体，用于制备PROTAC。

KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondral defects in their original location, leading to improved cartilage repair.

NBD-125 (B-12) 是berberine 的类似物。NBD-125 是RXRα的激活剂。NBD-125 在KM12C 细胞中的IC50值为31.10 μM。

AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg kg, and also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.

EMD-1204831 is a potent and highly selective c-Met inhibitor.

XMD-12, also known as DUN57447, Aurora inhibitor (compound 1) or Aurora-IN-1, is an Auroro inhibitor, which targets Aurora A B C. (5.6 18.4 24.6 nM).