cyanobacteria

β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) 是由蓝细菌产生的一种神经毒素，既有导致肌萎缩性侧索硬化症 (ALS) 以及其他可能的神经退行性疾病可能性。

ADDA is a non-proteinogenic amino acid existed in toxins produced by cyanobacteria.

ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported into plastids by a membrane-bound transporter.[3]

JRN73958 is an important precursor for the synthesis of scytonemin, also called Reduced scytonemin. Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin , representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin , representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity.

JMN13497 is an precursor compound to for synthesis of scytonemin. Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin , representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Microcystin-WR为蓝藻代谢产物中的一种微囊藻毒素，对小鼠表现出肝脏毒性。

Cy-FBP/SBPase-IN-1（compound S5）是一种针对蓝藻光合作用调节酶的Cy-FBP/SBPase抑制剂。该化合物能有效阻断卡尔文循环和光系统，从而减少蓝藻的光合效率。此外，Cy-FBP/SBPase-IN-1能抑制包括集胞藻PCC6803在内的蓝藻生长，并在人源细胞与斑马鱼模型中表现出良好的安全性。

L-Valine-d7 是氘代标记的 L-Valine。L-Valine ((S)-Valine) 是一种非线性有机材料，它会导致脂质过氧化和丙二醛 (MDA) 积累，并对蓝藻具有抑制作用。L-Valine 通过激活 PI3K/Akt 信号通路以及抑制精氨酸酶 (arginase) 来抑制耐多药细菌。

Grahamimycin B 对革兰氏阳性菌、革兰氏阴性菌、蓝藻和绿藻的活性较弱。

Euhalothece-362 是一种红移的孢氨酸样氨基酸，存在于单细胞蓝藻 (Euhalothecesp.) 中。Euhalothece-362 可用于研究微生物在高盐环境中的次级代谢。

Argimicin A 是从Sphingomonassp. 中分离出的一种抗生素，对有毒蓝藻展现溶藻活性，可抑制M. viridis和M. aeruginosa，IC50分别为12 ng/mL和100 ng/mL。

Menominin B 是一种在淡水海绵相关蓝藻 Nostoc sp. 中发现的环肽，展现出细胞毒性特性。它对卵巢癌细胞株 OVCAR3 具有抗增殖活性 (IC50为 2.4 μM)。这种化合物在抗癌研究中具有潜在应用价值。

Argimicin C 是从 Sphingomonas sp. 中提取的一种抗生素。该化合物对多种有毒蓝藻表现出杀藻活性，其最低抑菌浓度（MIC）为低微摩尔水平。

Argimicin B 是从 Sphingomonas sp. 中提取的抗生素，具有显著的杀藻活性，特别对多种有害蓝藻有效，其最低抑制浓度（MIC）达到微摩尔水平。

Cyanostatin B，一种蓝藻脂肽，是亮氨酸氨肽酶 (LAP) 的抑制剂，IC50为12 ng/mL。它对蛋白磷酸酶 (PP2A) 和血管紧张素转换酶 (ACE) 展现出轻微的抑制作用，其中ACE的IC50值为130 μg/mL。Cyanostatin B 对卤虫无恶性，但在体外对人类肝细胞表现出细胞毒性和遗传毒性，抑制HepG细胞增殖，并诱导DNA单链断裂且导致基因组不稳定性。

Oscillamide C (Compound 2) 是一种含脲基的环肽，作为蛋白磷酸酶 1 (PP1) 和蛋白磷酸酶 2A (PP2A) 的抑制剂，其对 PP1 和 PP2A 的IC50分别为0.90 μM 和1.33 μM。此化合物可从蓝藻Planktothrix agardhii和P. rubescens中分离，适用于癌症研究。

Oscillamide C (TFA) (Compound 2) 是一种抑制蛋白磷酸酶 1 (PP1) 和蛋白磷酸酶 2A (PP2A) 的脲基环肽，其对 PP1 和 PP2A 的 IC50 分别为 0.90 μM 和 1.33 μM。该化合物可从蓝藻 Planktothrix agardhii 和 P. rubescens 中提取，并在癌症研究中有潜在应用。