chaetomium

Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90 缺氧诱导因子1α 途径的抑制剂。

Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)

Myceliothermophin E is a polyketide-amino acid hybrid fungal metabolite that has been found inT. thermophilusand has anticancer and antimicrobial activities.1,2It is cytotoxic to DLD-1, Hep3B, HepG2, and HGC-27 cancer cells (IC50s = 0.32, 0.42, 0.26, and 0.08 μg/ml, respectively).1Myceliothermophin E is active against methicillin-resistant, but not -sensitive,S. aureus(MICs = 15.8 and >100 μM, respectively).2 1.Gao, Y.-L., Zhang, M.-L., Wang, X., et al.Isolation and characterization of a new cytotoxic polyketide-amino acid hybrid from Thermothelomyces thermophilus ATCC 42464Nat. Prod. Res.Epub ahead of print(2019) 2.Wang, X., Zhao, L., Liu, C., et al.New tetramic acids comprising of decalin and pyridones from Chaetomium olivaceum SD-80A with antimicrobial activityFront. Microbiol.102958(2020)

Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cancer cells. 1.Tabata, N., Suzumura, Y., Tomoda, H., et al.Xanthoquinodins, new anticoccidial agents produced by Humicola sp. Production, isolation and physico-chemical and biological propertiesJ. Antibiot. (Tokyo)46(5)749-755(1993) 2.Tantapakul, C., Promgool, T., Kanokmedhakul, K., et al.Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) MartNat. Prod. Res.34(4)494-502(2020)

Chaetocin 特异性抑制组蛋白甲基转移酶(HMT) SU(VAR)3-9，IC50值为0.6 μM。它还可抑制硫氧还蛋白还原酶，IC50值为4 μM。

11-epi-Chaetomugilin I 是一种在Chaetomium globosum 中发现的代谢物。11-epi-Chaetomugilin I 对小鼠 P388 白血病细胞系、人类 HL-60 白血病细胞系、小鼠 L1210 白血病细胞系和人类 KB 表皮样癌细胞系具有显著的细胞毒性活性。

Cochliodone A 是一种从深海衍生真菌Chaetomium sp.培养物中分离的活性化合物，展示出了抗细菌和抗癌的特性。该化合物对多种细菌显示出有效的抑制作用，其最小抑菌浓度（MICs）分别为：V. vulnificus 15.3 μg mL，V. rotiferianus 32.7 μg mL，S. aureus ATCC 43300 15.9 μg mL 和 S. aureus CGMCC 1.12409 16.3 μg mL。Cochliodone A 同时对不同的癌细胞系也有抑制效果，其半数抑制浓度（IC50s）分别为：A549 28.1 μM，HeLa 20.7 μM，和 Hep G2 23.2 μM。

Chaetoglobosin C (Compound 4)，源自真菌Chaetomium globosum KMITL-N0802，为一种蒽醌-色酮类化合物，具备抗结核分枝杆菌的活性。

Semicochliodinol 是可以从属于毛壳真菌 (genus Chaetomium) 的水稻培养物中分离出的化合物。

chaetoglobosin Vb 是一种从内生球藻中分离出来的新型细胞松弛素生物碱。

Chaetoviridin A, an azaphilone isolated from Chaetomium globosum, is characterized as 6H-furo[2,3-h]isochromene-6,8(6aH)-dione with substitutions including a chloro group at position 5, a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a, and a 3-methylpent-1-en-1yl group at position 3. It exhibits antifungal activity against plant pathogenic fungi.