ceramide

A potent modulator of cell proliferation and differentiation.

C16 dihydro Ceramide (d18:0 16:0) (Cer(d18:0 16:0)) 是合成神经酰胺的前体，诱导核周区域自噬，可用于研究细胞膜的稳定性和神经系统疾病。

C22 Ceramide (d18:1 22:0) (C22 Ceramide) 是一种从海绵Haliclona koremella 中分离出含有山嵛酸的长链神经酰胺，是一种内源性生物活性鞘脂。C22 Ceramide (d18:1 22:0) 可特异性抑制MCSR，降低离体大鼠肝线粒体和脂质体中 C16-神经酰胺通道的形成。

N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂，也是人体 AML 细胞神经酰胺代谢的有效调节因子，可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。

Aureobasidin A 是一种环肽和抗真菌抗生素。它是肌醇磷酸神经酰胺合酶 AUR1 的抑制剂。

C17 dihydro Ceramide (d18:0 17:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1388156-40-8。

C12((±)-2'-hydroxy) dihydro Ceramide (d18:0 12:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 2377379-54-7。

C32 Ceramide (d18:1 32:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 34227-73-1。

BODIPY-C12 Ceramide（B12Cer）是C12鞘氨醇的荧光标记形式，其激发 发射最大值分别为505 540 nm。BODIPY-C12 Ceramide 是一种带有荧光标记的神经酰胺。BODIPY-C12 Ceramide已被用于量化尼曼-匹克病患者血浆中酸性鞘磷脂酶的活性。

C10 Ceramide (d18:1 10:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 111122-57-7。

C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy.

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 190249-36-6。

C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM).

(±)-2'-hydroxy Ceramide (d18:0 18:0)' 为一种鞘磷脂，能够自 ADP 刺激下的哺乳动物血小板中提取。

C-6 NBD-dihydro-Ceramide是一种生物活性的短链荧光类似物，能够透过细胞膜。

C12-Ceramide (C12 Ceramide (d18:1 12:0)) 是一种存在于先兆子痫妇女所生婴儿围绕脐带血管的保护膜的神经酰胺，是 C12 鞘磷脂被酸性鞘磷脂酶（ASM）水解后形成的，可用于评估 A 型或 B 型尼曼-皮克病患者血浆中的 ASM 活性水平。

Ceramide 1-phosphate 是一种具有生物活性的脂质，同时也是鞘脂的重要组成部分之一。它在细胞分化、迁移、增殖和死亡等细胞活动中发挥多重作用。

C8 PEG-Ceramide 是一种脂质产品。C8 PEG-Ceramide 可合成脂质双层载体，用于药物递送。

C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。

C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg ml.

C16 Ceramide-1-phosphate (d18:1 16:0) ammonium salt (C16 C1P ammonium salt) 是一种酯类产品，可用于合成纳米生物制。

Ceramide 1 A 是一种蜡状脂质化合物，是顶端皮肤层的脂质。它具有特殊的分子结构，因为它含有一种与长链ω-羟基酸相连的亚油酸。

Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi lumen. In mammals, it is biosynthesized by sphingomyelin synthase 2 (SMS2) in the plasma membrane and by sphingomyelin synthase-related protein (SMSr) in the endoplasmic reticulum (ER). In Drosophila, CPE has a role in glial ensheathment of axons. Disrupting CPE synthesis by depleting SMSr in vitro in mammalian cells leads to an accumulation of ER ceramides, which are then mislocalized to the mitochondria, inducing apoptosis. However, ceramide levels are not altered in transgenic mice lacking SMSr catalytic activity. CPEs (bovine) is a mixture of CPEs with variable N-acyl chain lengths.

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7 Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis.[3]