cdo-1

Expression system: E. coli
Length: 1-200, Full Length
Activity: Not Tested

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta Serrate Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). DLL3 Protein, Cynomolgus, Recombinant (aa 27-488, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 49.21 kDa and the accession number is A0A2K5WSR1.

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta Serrate Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). DLL3 Protein, Cynomolgus, Recombinant (aa 27-477, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 48.80 kDa and the accession number is A0A2K5WSR1.

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta Serrate Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). DLL3 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51 kDa and the accession number is F6TFV4.

Expression system: HEK293 Cells
Length: 25-488, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 311-479, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 311-479, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 27-215, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 27-490, Partial
Activity: ELISA、SPR

Expression system: HEK293 Cells
Length: 27-490, Partial
Activity: ELISA

Cell adhesion molecule-related, down-regulated by oncogenes (CDON), also known as CDO, is an Ig superfamily member, is a component of a cell surface receptor that positively regulates skeletal myogenesis. Brother of CDO (BOC) is a cell surface receptor that derives its name from the structurally related protein, CDON. They are components of a cell surface receptor that positively regulates myogenesis in vitro. Expression of Cdo and Boc in myoblast cell lines is downregulated by the ras oncogene, and forced re-expression of either Cdo or Boc can override ras-induced inhibition of myogenic differentiation. CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. CDON binds to Bnip-2 and JLP, scaffold proteins for Cdc42 and p38alpha beta MAPK, respectively. The Bnip-2 Cdc42 and JLP p38alpha beta complexes associate in a CDON-dependent manner, resulting in Bnip-2 Cdc42-dependent p38alpha beta activation and stimulation of cell differentiation. It is proposed that CDO mediates, at least in part, the effects of cell-cell interactions between muscle precursors that are critical in myogenesis.