CNP, a member of the natriureticpeptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs shar
C-TypeNatriureticPeptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriureticpeptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by histamine, 5-HT, or Forskolin. Additionally, CNP exhibits strong endothelial-derived relaxation properties and acts as a growth inhibitor.
Nesiritide is the recombinant form of the 32 amino acid human B-typenatriureticpeptide, which is normally produced by the ventricular myocardium. It is an agonist of natriureticpeptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR