apaf-1

NS3694 是一种凋亡抑制剂，可抑制凋亡小体形成和半胱天冬酶活化。

trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物，是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂，具有抗真菌和抗癌活性。

QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).

ZYZ-488 是一种凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂，抑制 procaspase-9 和 procaspase-3 激活，可用于研究心血管疾病。

MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂，可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。

LPT-99 是一种凋亡蛋白酶活化因子 1 (APAF-1) 的拮抗剂，能够抑制蛋白酶原 9 (procaspase-9) 的激活。它还可抑制 Cisplatin 诱导的细胞凋亡 (apoptosis)，并有效减轻 Cisplatin 导致的大鼠听力损失。

Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 μM. These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.

HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.

Cytochrome c fragment (93-108) is a peptide from Cytochrome c, which is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions1. Cytochrome c is a required cofactor for Apaf-1 function2.

Cytochrome P450 CYP1B1 (190-198) [Homo sapiens] is a peptide from Cytochrome c, which is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions1. Cytochrome c is a required cofactor for Apaf-1 function2.