amine-peg-thiol

Amine-PEG-thiol (MW 3400) is a polyethylene glycol (PEG)-based linker molecule containing an amine group and a thiol group. It serves as an essential component in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker employed in PROTAC synthesis[1].

Amine-PEG-thiol (MW 5000) is a polyethylene glycol (PEG) based PROTAC linker, primarily utilized for the synthesis of PROTACs[1].

HS-PEG3-CH2CH2NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HS-PEG5-CH2CH2NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HS-PEG7-CH2CH2NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Stearic acid-PEG-CH2CO2H (MW 3400) 是一种亲脂性硫醇反应性PEG聚合物。硬脂酸部分用于包封疏水性治疗剂，而PEG链提高整体水溶性及生物相容性。在活化剂（如HATU或EDC）存在下，羧酸（-COOH）与胺（-NH2）通过缩合产生稳定的酰胺键。试剂级，仅供研究使用。

Mal-PEG5-amine 是一种包含马来酰亚胺基团和胺基团的 PEG 连接体。其亲水的 PEG 间隔物可以提高在水性介质中的溶解度。胺基团能够与羧酸、活化 NHS 酯、羰基（酮、醛）等发生反应。马来酰亚胺基团则会与硫醇基团反应以形成共价键，将生物分子与硫醇连接。

Mal-PEG4-amine 是一种包含马来酰亚胺基团和胺基团的 PEG 连接体。亲水性 PEG 间隔物提高了其在水性介质中的溶解性。胺基团能够与羧酸、活化 NHS 酯及羰基（酮、醛）等化合物发生反应。马来酰亚胺基团则与硫醇基团反应形成共价键，用于结合含硫醇的生物分子。

Mal-PEG5-NH-Boc 是一种包括马来酰亚胺基团和 Boc 保护胺基的 PEG 连接体。其亲水性的 PEG 间隔物能够提高其在水溶液中的溶解性。胺在酸性条件下可去除保护。马来酰亚胺基团能够与硫醇基团反应，生成共价键。

Iodoacetamido-PEG3-NHS ester 是一种包含碘乙酰胺基团以及 Boc 保护氨基的 PEG 试剂。碘乙酰胺基团是一种烷基化剂，能够与硫醇基团共价结合。Boc 基团可以在温和的酸性条件下去保护，形成游离胺。

Iodoacetamido-PEG8-acid 是一种包含碘乙酰胺基团和羧酸结构的 PEG 试剂。在活化剂（例如 EDC 或 HATU）的作用下，其末端羧酸能够与一级胺基团反应，生成稳定的酰胺键。碘乙酰胺基团可作为烷基化剂，用于与硫醇基团进行共价结合。

Mal-PEG4-NH-Boc 是含有马来酰亚胺基团和Boc保护胺基团的PEG连接体。该亲水性PEG间隔物增强其在水性介质中的溶解度，保护的胺基在酸性条件下可以去保护。马来酰亚胺基团可与硫醇基团反应生成共价键。

NHS ester-C2-NHCO-C2-NHS 是一种异双功能 PEG 接头，末端包含 NHS 酯，适用于标记胺化合物和马来酰亚胺基团，以便与硫醇基团进行反应。