adrenomedullin , rat

Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.

Adrenomedullin (1-50), rat, is a 50 amino acid peptide hormone that induces selective arterial vasodilation via CGRP1 receptor activation, with RNA expression in rat adrenal glands, lung, kidney, heart, and spleen.

Adrenomedullin(rat) 为一种由内皮细胞（EC）与血管平滑肌细胞（VSMC）分泌的有效血管舒张肽。

Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52) . In vitro, adrenomedullin (22-52) reduces basal corticosterone production in a mixture of rat adrenocortical and adrenomedulllary cells. It also reverses increases in ACTH-stimulated corticosterone production induced by adrenomedullin (1-52). Adrenomedulin (22-52) (0.5 and 5 μg/kg/min) has no effect on basal regional cerebral blood flow but reverses increases in regional cerebral blood flow induced by rat adrenomedullin in rats. Unlike adrenomedullin (1-52), adrenomedullin (22-52) has no effect on mesenteric arterial perfusion pressure in cats.

Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) . It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II and endothelin-1 from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure. It also potentiates inflammatory edema and neutrophil accumulation in rats.

Adrenomedullin(16-31), human TFA 为人类肾上腺髓质素(hADM)之16至31氨基酸片段，对CGRP1受体显示高亲和力。该化合物在大鼠体内可提高全身血压，但对猫无效。

Adrenomedullin(porcine)是一種多肽，具有调节血管舒张的功能。它在内皮依赖性条件下能诱导大鼠主动脉舒张，IC50为2.4 nM；在内皮非依赖性条件下则能诱导猪冠状动脉舒张，IC50为27.6 nM。

Pro-Adrenomedullin (N-20), rat 是多肽分子，其序列是 ARLDTSSQFRKKWNKWALSR-NH2。