a:cholesterol

Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 抑制剂，EC50为 9 nM。它抑制 ACAT2，EC50为 368 nM。它诱导细胞凋亡，具有抗肾上腺皮质癌的潜力。

Cholesterol 24-hydroxylase-IN-1 是一种能透过血脑屏障且具有口服活性、选择性和高效性的的胆固醇24-羟化酶(CH24H or CYP46A1)抑制剂。Cholesterol 24-hydroxylase-IN-1 可用于研究癫痫类的神经系统疾病。

Cholesterol 是哺乳动物中主要的固醇，约占质膜结构的 20–25%，在调控膜的流动性、渗透性及蛋白功能中发挥关键作用。它是内源性雌激素相关受体 α（ERRα）的激动剂，广泛参与代谢调节，也是激素和胆汁酸合成的前体。实验中常用于高血脂模型的构建。

Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver.

Cholesterol24-hydroxylase-IN-3 是一种选择性强、能穿过血脑屏障的口服 CH24H 抑制剂 (IC50= 23 nM)，归属于 1,3-恶唑衍生物。Cholesterol24-hydroxylase-IN-3 通过其1,3-恶唑氮原子与血红素铁结合，同时环丙基占据疏水口袋，竞争性抑制CH24H酶的活性。用于研究癫痫等神经系统疾病。

Cholesteroloxidase-IN-1 (Compound 4) 是胆固醇氧化酶 (Cholesteroloxidase) 的一种抑制剂，具有卓越的结合亲和力，可用于研究感染和炎症疾病。

4β-hydroxy Cholesterol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T21530，CAS号为 17320-10-4。

22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .

Cholesterol β-D-Glucoside (β-D-Glucopyranoside) 是由人类寄生虫幽门螺杆菌产生的毒性物质。

Cholesterol n-Octanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65073，CAS号为 1182-42-9。

胆固醇酯酶 (Cholesterol esterase) 是一种在肠道内将胆固醇酯水解为胆固醇和游离脂肪酸的酶。胆固醇在腺泡细胞中合成，储存在酶原颗粒中。胆固醇酯酶又称胆盐刺激脂肪酶、羧基酯脂肪酶，具有促进胆固醇吸收的作用。

Cholesterol-PEG-Folate (MW 2000) 是一种辅料，可用于制备叶酸偶联 PEG 脂质体。

Cholesterol24-Hydroxylase-IN-2为胆固醇24-羟化酶（CH24H 或CYP46A1）抑制剂，具有5.4 nM的IC50值。该化合物适用于哺乳动物胆固醇24-羟化酶的成像研究。

Biotin-cholesterol为Cholesterol的生物素化衍生物，适用于合成药物输送用的生物素缀合脂质体和胶束。

GlucosamineCholesterol(N-Cholesteryl succinyl glucosamine)，一种基于葡萄糖胺的脂质缀合物，适用于脂质纳米颗粒(LNP)的制备。

19-Alkyne Cholesterol, an alkyne-derivatized form of cholesterol, is utilized to trace its localization and distribution within subcellular compartments of NIH3T3 cells and to explore cholesterol's involvement in hedgehog (Hh) signal transduction within Shh-LIGHT2 cells through click chemistry alongside diverse reporter azides.

22-NBD cholesterol, a fluorescent cholesterol analog featuring a nitrobenzoxadiazole (NBD) group, serves multiple research purposes in both in vitro and in vivo settings. Its applications span the analysis of steroid uptake and esterification, the study of intracellular localization and targeting, cholesterol metabolism in mammalian and bacterial cells, and examining cholesterol intestinal absorption in hamsters. This compound showcases excitation/emission maxima at 472/540 nm when integrated into 1,2-dimyristoyl-sn-glycero-3-PC (DMPC) vesicles. Notably, the emission maximum of 22-NBD cholesterol varies with the solvent's polarity, becoming more pronounced as the polarity increases.

27-Alkyne Cholesterol, an alkyne derivative of cholesterol, facilitates the investigation of cholesterol metabolism and localization through click chemistry with reporter azides in both fixed and living cells. It serves as a substrate for enzymes across diverse species such as bacteria, yeast, rat, and human.

7-Keto-25-hydroxy Cholesterol, an oxysterol and proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol, binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. Additionally, it enhances the number of EGF high affinity binding sites in normal rat kidney (NRK) cells.

Cholesterol-PEG 600 是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

AlkyneCholesterol是一种修饰后的脂质，包含炔烃基团并作为点击化学试剂。在铜 (Cu) 催化剂的作用下，末端炔基能与含叠氮化物试剂进行高度特异性的连接反应。AlkyneCholesterol还被用于追踪细胞胆固醇的代谢与定位。

Cholesterol-undecanoate-glucose conjugate 是一种胆固醇共轭物，被应用于鼻内脂质体疫苗的合成，亦用于药物递送研究。

Cholesterol-doxorubicin 是一种胆固醇耦联物，具备优良的储存稳定性、较低的血液毒性和可控的药物输送特性，适用于药物递送研究。