α glucosidase

α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate. It plays a vital role in facilitating glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM).

α-Glucosidase-IN-4 是一种有效的α- 葡萄糖苷酶 (α-glucosidase)抑制剂，具有降血压和降糖活性。

α-Amylase/α-Glucosidase-IN-1 (compound 33) 是一种有效的α-淀粉酶/α-葡萄糖苷酶抑制剂，对α-淀粉酶和 α-葡萄糖苷酶的IC50值分别为 2.01、2.09 μM。动力学研究预测α-Amylase/α-Glucosidase-IN-1 具有抗高血糖的潜力。

α-Glucosidase-IN-8 (Compound 4k) is a potent, competitive inhibitor of α-glucosidase. It displays an impressive IC50 value of 0.18 μg/mL [1].

α-Glucosidase-IN-9 (compound 7) is a highly potent α-glucosidase inhibitor with an IC50 of 55.6 μM, making it suitable for type II diabetes research [1].

α-Glucosidase-IN-16 is a highly effective and orally bioavailable inhibitor of α-glucosidase, displaying a remarkable IC50 value of 3.28 μM. This compound demonstrates the ability to significantly decrease blood glucose levels in diabetic rats induced by Streptozotocin. Notably, α-Glucosidase-IN-16 also exhibits noteworthy antidiabetic activity [1].

α-Glucosidase-IN-2 (compound 5d) 是一种有效的α-Glucosidase 抑制剂，IC50of 9.48 μM。α-Glucosidase-IN-2 是一种抗糖尿病药物。

α-Glucosidase-IN-20 (Compound 3B) is a highly effective and orally active inhibitor of α-glucosidase. It exhibits potent anti-diabetic properties, as evidenced by its IC50 value of 3.01 μM [1].

α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM. It possesses antidiabetic properties [1].

α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1].

α-Amylase/α-Glucosidase-IN-2 (compound 5) exhibits strong inhibition activity towards both α-amylase and α-glucosidase enzymes, with IC 50 values of 13.02 μM and 13.09 μM, respectively. This compound shows promise for investigating diabetic complications [1].

α-Glucosidase-IN-21 (Compound 2B) is a highly potent and orally bioavailable inhibitor of α-glucosidase. With an impressive IC50 value of 2.62 μM, this compound exhibits remarkable anti-diabetic properties [1].

α-Glucosidase-IN-11 是一种高渗透性的 α-葡萄糖苷酶 (α-glucosidase) 的竞争性抑制剂 (IC50: 0.56 μM)。α-Glucosidase-IN-11 能够结合 α-葡萄糖苷酶中 Trp 残基，对蛋白质的折叠具有调节作用，能够用于血糖水平的调节。

α-Glucosidase-IN-19 (Compound 6B) 是一种口服具有活力的 α-glucosidase 抑制剂 (IC50: 3.63 μM)，具有抗糖尿病作用。

α-Glucosidase-IN-17 (Compound 12B) 是一种有效的、具有口服活性的α-glucosidase 抑制剂，IC50为 3.79 μM。α-Glucosidase-IN-17 具有抗糖尿病活性。

α-Glucosidase-IN-10 (compound 13) 是一种 α-glucosidase 的有效抑制剂 (IC50: 92.7 μM)。α-Glucosidase-IN-10 能够用于研究 II 型糖尿病。

α-Glucosidase-IN-6 是 α-glucosidase 的竞争性抑制剂 (IC50: 5.69 μM)，表现出抗糖尿病的研究潜力。

α-Glucosidase-IN-13 是 α-glucosidase 抑制剂 (IC50: 5.69 μM)。

α-Glucosidase-IN-14 是 α- 葡萄糖苷酶 (α-glucosidase) 的有效抑制剂 (IC50: 5.22 μM)。

α-Glucosidase-IN-12 是 α- 葡萄糖苷酶 (α-glucosidase) 的有效抑制剂 (IC50: 10.20 μM)。

α-Glucosidase-IN-3 是一种针对 α-葡萄糖苷酶和 α-淀粉酶的齐墩果酸肟酯衍生物，对α-葡萄糖苷酶的 IC50 值为 0.35 μM。

α-Glucosidase-IN-24 (Compound 13) 是一种α-Glucosidase 抑制剂，IC50为 451 μM，可以从Swertia kouitchensis 中分离得到。

α-Glucosidase-IN-26（化合物 7i）是一种有效的α-glucosidase抑制剂，其半抑制浓度（IC50）为4.63 µM，适用于2型糖尿病（T2DM）的研究。

α-Glucosidase-IN-28（Compound 18）是一种有效的α-Glucosidase抑制剂，具有IC50为0.62 μM和Ki为3.93μM。该化合物通过与α-Glucosidase的OBS区域结合以及与周围氨基酸建立多重疏水作用力，展现抑制活性。它主要用于研究糖尿病及其相关疾病。