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NKG2D/CD314 Protein, Mouse, Recombinant (His)

NKG2D/CD314 Protein, Mouse, Recombinant (His)

产品编号 TMPJ-00122
别名: KLR, NKG2-D type II integral membrane protein, CD314, NKG2-D-activating NK receptor, KLRK1, CD314 antigen, member 1, NKG2-D, NK cell receptor D, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K

NKG2D/CD314 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is O54709.

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NKG2D/CD314 Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 670 5日内发货
50 μg ¥ 2,040 5日内发货
500 μg ¥ 10,200 5日内发货
1 mg ¥ 15,300 5日内发货
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产品目录号及名称: NKG2D/CD314 Protein, Mouse, Recombinant (His) (TMPJ-00122)
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产品描述 NKG2D/CD314 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is O54709.
种属 Mouse
表达系统 HEK293 Cells
标签 N-6xHis
蛋白编号 O54709
别名 KLR, NKG2-D type II integral membrane protein, CD314, NKG2-D-activating NK receptor, KLRK1, CD314 antigen, member 1, NKG2-D, NK cell receptor D, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K
氨基酸序列 Phe94
蛋白构建 Phe94 - Val232
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 20-30 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

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Keywords

NKG2D/CD314 Protein, Mouse, Recombinant (His) KLR KLRK 1 NKG2-D type II integral membrane protein CD314 CD-314 NKG2-D-activating NK receptor KLRK1 CD 314 CD314 antigen member 1 KLRK-1 NKG2-D NK cell receptor D Killer cell lectin-like receptor subfamily K member 1 killer cell lectin-like receptor subfamily K recombinant recombinant-proteins proteins protein

 

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