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IL-6R Protein, Rat, Recombinant (His)

产品编号 TMPY-02560

IL-6R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is A6J6I0.

IL-6R Protein, Rat, Recombinant (His)

产品编号 TMPY-02560

IL-6R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is A6J6I0.

规格	价格	库存
5 μg	¥ 785	6-8日内发货
10 μg	¥ 1,320	6-8日内发货
20 μg	¥ 2,220	6-8日内发货
50 μg	¥ 4,430	6-8日内发货

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产品信息

生物活性	Measured by its ability to bind human IL6 in functional ELISA.
产品描述	IL-6R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is A6J6I0.
种属	Rat
表达系统	HEK293 Cells
标签	C-His
蛋白编号	A6J6I0
别名	interleukin 6 receptor
蛋白构建	A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 20
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	39.5 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy