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IL-5R alpha/CD125 Protein, Human, Recombinant (hFc)

IL-5R alpha/CD125 Protein, Human, Recombinant (hFc)

产品编号 TMPJ-00266
别名: IL5R, CDw125, IL-5R-alpha, IL-5R-α, IL-5 receptor subunit α, CD125, IL-5 receptor subunit alpha, IL-5R subunit alpha, Interleukin-5 receptor subunit alpha, IL-5RA, Interleukin-5 receptor subunit α, IL-5R subunit α, IL5RA

IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-85 KDa and the accession number is Q01344.

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IL-5R alpha/CD125 Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 1,170 5日内发货
50 μg ¥ 3,470 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 18,900 5日内发货
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产品目录号及名称: IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) (TMPJ-00266)
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产品描述 IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-85 KDa and the accession number is Q01344.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 Q01344
别名 IL5R, CDw125, IL-5R-alpha, IL-5R-α, IL-5 receptor subunit α, CD125, IL-5 receptor subunit alpha, IL-5R subunit alpha, Interleukin-5 receptor subunit alpha, IL-5RA, Interleukin-5 receptor subunit α, IL-5R subunit α, IL5RA
氨基酸序列 Asp21-Glu335
蛋白构建 Asp21-Glu335
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 70-85 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Interleukin-5 Receptor alpha (IL-5Rα, CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 Rα consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif, a 20 aa transmembrane segment, and a 58 aa cytoplasmic domain. Within the ECD, human IL-5Rα shares 71% aa sequence identity with mouse and rat IL-5 Rα. Alternate splicing of human IL-5 Rα generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Rα and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 Rα binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5Rα followed by eosinophilic differentiation and activation.

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Keywords

IL-5R alpha/CD125 Protein, Human, Recombinant (hFc) IL5R CDw125 IL-5R-alpha IL-5R-α CD-125 IL-5 receptor subunit α CD 125 CD125 IL-5 receptor subunit alpha IL-5R subunit alpha Interleukin-5 receptor subunit alpha IL-5RA Interleukin-5 receptor subunit α IL-5R subunit α IL5RA recombinant recombinant-proteins proteins protein

 

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