IL-18R alpha Protein, Mouse, Recombinant (mFc)

IL-18R alpha Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.74 kDa and the accession number is Q61098.

规格	价格/CNY		数量
50 μg	￥ 2,520	现货
100 μg	￥ 4,320	5日内发货
200 μg	￥ 7,380	5日内发货
500 μg	￥ 14,930	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 2,520

现货

100 μg

￥ 4,320

5日内发货

200 μg

￥ 7,380

5日内发货

500 μg

￥ 14,930

5日内发货

生物活性	Measured by its binding ability in a functional ELISA. Immobilized mIL18R1-mFc(mIgG2a) at 10 μg/mL (100 μL/well) can bind mIL18/Biotin , the EC50 of mIL18/Biotin is 90-260 ng/mL.
产品描述	IL-18R alpha Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.74 kDa and the accession number is Q61098.

种属	Mouse
表达系统	HEK293 Cells
标签	C-mFc
蛋白编号	Q61098
别名	Il18rα, Il1rrp, interleukin 18 receptor 1, Il18ralpha
蛋白构建	The Mouse IL18R1 (NP_032391.1) (Met1-Gly326) was expressed with the Fc region of Mouse IgG2a at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	61.74 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.