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FGF-19 Protein, Human, Recombinant (Active)

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产品编号 TMPX-00008

FGF-19 Protein, Human, Recombinant (Active) is expressed in E. coli. The accession number is O95750.

FGF-19 Protein, Human, Recombinant (Active)

一键复制产品信息

产品编号 TMPX-00008

FGF-19 Protein, Human, Recombinant (Active) is expressed in E. coli. The accession number is O95750.

规格	价格	库存
5 μg	¥ 569	6-8日内发货
10 μg	¥ 962	6-8日内发货
20 μg	¥ 1,630	5日内发货
50 μg	¥ 2,790	5日内发货
100 μg	¥ 4,760	5日内发货

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产品信息

生物活性	Fully biologically active when compared to standard. The biological activity is measured by its binding ability in a functional ELISA. Immobilized rHuFGF R4 at 5 µg/ml can bind rHuFGF-19 with a linear range of 3-200 ng/ml. Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/ml, corresponding to a specific activity of > 6.7 × 10^3 IU/mg.
产品描述	FGF-19 Protein, Human, Recombinant (Active) is expressed in E. coli. The accession number is O95750.
种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	O95750
别名	Fibroblast growth factor 19,FGF-19,FGF19
蛋白构建	Arg23-Lys216
蛋白纯度	> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
分子量	21.8 kDa (Predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Human FGF-19 is encoded by the FGF19 gene. FGF-19 belongs to the FGF-19 subfamily which has three members FGF-19, 21, 23. FGFs are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis. By contrast, the FGF-19 subfamily has recently been shown to function in an endocrine manner. Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation. β-Klotho has been identified as co-factor required for FGF-19, 21, 23 signaling. It can obviously increase ligand-receptor affinity. Unlike most FGFs which bind to and activate more than one FGF receptor, FGF19 is a specific ligand for FGF R4. In FGF-19 transgenic mice, reducing liver triglycerides, increasing fatty acid oxidation, reducing glucose levels and improving insulin sensitivity can be observed.