Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ecamsule disodium is a versatile UVA filter compound commonly employed in the formulation of sunscreen products. Its primary role is to mitigate the potential harm posed by solar radiation through the prevention of various biological repercussions induced by UV exposure. These include the inhibition of pyrimidine dimer formation, the reduction of p53 protein accumulation, and the downregulation of collagenase 2 expression.
产品描述 | Ecamsule disodium is a versatile UVA filter compound commonly employed in the formulation of sunscreen products. Its primary role is to mitigate the potential harm posed by solar radiation through the prevention of various biological repercussions induced by UV exposure. These include the inhibition of pyrimidine dimer formation, the reduction of p53 protein accumulation, and the downregulation of collagenase 2 expression. |
体外活性 | Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1]. |
分子量 | 585.68 |
分子式 | C28H34NaO8S2 |
CAS No. | 90458-75-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ecamsule disodium 90458-75-6 Ecamsule Inhibitor inhibitor inhibit