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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RNF146 Polyclonal Antibody

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货号 TMAB-01623

别名 RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin

Anti-RNF146 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF146。Anti-RNF146 Polyclonal Antibody 可用于 ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB。

Anti-RNF146 Polyclonal Antibody

Anti-RNF146 Polyclonal Antibody

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货号 TMAB-01623 别名 RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin

Anti-RNF146 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF146。Anti-RNF146 Polyclonal Antibody 可用于 ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
别名RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Ig Type
IgG
反应种属
(predicted:Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse)
应用ELISAICC/IFIFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
组织特异性Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF146 (RING finger protein 146), also known as Dactylidin, is a 359 amino acid protein that contains one RING-type zinc finger and one WWE domain. Via its RING-type zinc finger, RNF146 may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF146 are associated with Alzheimer's disease (AD) and may lead to a higher risk of breast cancer. Two isoforms of RNF146 exist due to alternative splicing events.
抗原信息
免疫原
KLH conjugated synthetic peptide: human RNF146
抗原种属
Human
基因名称
RNF146
基因ID
81847
蛋白名称
E3 ubiquitin-protein ligase RNF146
Uniprot ID
Q9NTX7
研究领域
Alzheimer's disease
功能
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination.
化学信息
分子量Theoretical: 39 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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