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Anti-RNF146 Polyclonal Antibody
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产品编号 TMAB-01623
别名 RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Anti-RNF146 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF146。Anti-RNF146 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA。
Anti-RNF146 Polyclonal Antibody
Anti-RNF146 Polyclonal Antibody
还可以产品编号 TMAB-01623 别名 RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin
Anti-RNF146 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF146。Anti-RNF146 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-RNF146 Polyclonal Antibody is a Rabbit antibody targeting RNF146. Anti-RNF146 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
| 疾病造模方案 | |
| 别名 | RP3 351K20.1, RNF 146, RN146, RING finger protein 146, E3 ubiquitin-protein ligase rnf146, DKFZP434O1427, dJ351K20.1, Dactylidin |
| Ig Type | IgG |
| 交叉反应 | (predicted:Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding. |
| 组织特异性 | Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 免疫原 | KLH conjugated synthetic peptide: human RNF146 |
| 抗原种属 | Human |
| 基因名称 | RNF146 |
| 基因ID | |
| 蛋白名称 | E3 ubiquitin-protein ligase RNF146 |
| Uniprot ID | |
| 研究领域 | Alzheimer's disease |
| 功能 | E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination. |
| 分子量 | Theoretical: 39 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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