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Anti-Proteoglycan 4 Polyclonal Antibody
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产品编号 TMAB-01582
别名 SZP, Superficial zone proteoglycan, Proteoglycan 4, PRG4, MSF, Megakaryocyte-stimulating factor, Lubricin
Anti-Proteoglycan 4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Proteoglycan 4。Anti-Proteoglycan 4 Polyclonal Antibody 可用于 WB。
Anti-Proteoglycan 4 Polyclonal Antibody
Anti-Proteoglycan 4 Polyclonal Antibody
还可以产品编号 TMAB-01582 别名 SZP, Superficial zone proteoglycan, Proteoglycan 4, PRG4, MSF, Megakaryocyte-stimulating factor, Lubricin
Anti-Proteoglycan 4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Proteoglycan 4。Anti-Proteoglycan 4 Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,975 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-Proteoglycan 4 Polyclonal Antibody is a Rabbit antibody targeting Proteoglycan 4. Anti-Proteoglycan 4 Polyclonal Antibody can be used in WB. |
| 疾病造模方案 | |
| 别名 | SZP, Superficial zone proteoglycan, Proteoglycan 4, PRG4, MSF, Megakaryocyte-stimulating factor, Lubricin |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Human LO2 cell lysates Primary: Anti-Lubricin (TMAB-01582) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 152 kDa Observed band size: 160 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights. |
| 免疫原 | KLH conjugated synthetic peptide: human Lubricin/SZP |
| 抗原种属 | Human |
| 基因名称 | PRG4 |
| 基因ID | |
| 蛋白名称 | Proteoglycan 4 |
| Uniprot ID | |
| 研究领域 | Bone |
| 功能 | Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder. |
| 分子量 | Theoretical: 152 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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