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顶部生物活性储存和溶解信息计算器

Anti-Phospho-PP2A (Tyr307) Antibody (2E533)

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Anti-Phospho-PP2A (Tyr307) Antibody (2E533)
产品编号 TMAC-03254
别名 p-PP2A (Y307), p-PP2A (Tyr307), PP2A (p-Y307), PP2A (p-Tyr307)

Anti-Phospho-PP2A (Y307) Antibody (2E533) 是一种 Rabbit 抗体，靶向 Phospho-PP2A (Y307)。Anti-Phospho-PP2A (Y307) Antibody (2E533) 可用于 WB,ICC/IF,IHC,IP。

Anti-Phospho-PP2A (Tyr307) Antibody (2E533)

Anti-Phospho-PP2A (Tyr307) Antibody (2E533)

Rating icon 还可以
Anti-Phospho-PP2A (Tyr307) Antibody (2E533)
产品编号 TMAC-03254 别名 p-PP2A (Y307), p-PP2A (Tyr307), PP2A (p-Y307), PP2A (p-Tyr307)

Anti-Phospho-PP2A (Y307) Antibody (2E533) 是一种 Rabbit 抗体，靶向 Phospho-PP2A (Y307)。Anti-Phospho-PP2A (Y307) Antibody (2E533) 可用于 WB,ICC/IF,IHC,IP。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,480
5日内发货
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生物活性
产品描述
Anti-Phospho-PP2A (Tyr307) Antibody (2E533) 是一种 Rabbit 抗体，靶向 Phospho-PP2A (Tyr307)。Anti-Phospho-PP2A (Tyr307) Antibody (2E533) 可用于 WB,ICC/IF,IHC,IP。
别名p-PP2A (Y307), p-PP2A (Tyr307), PP2A (p-Y307), PP2A (p-Tyr307)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Phospho-PP2A (pY307) on different lysates using anti-Phospho-PP2A (pY307) antibody at 1/1,000 dilution. Positive control: Lane 1: A431, Lane 2: F9, Lane 3: PC12.
2. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Phospho-PP2A (pY307) antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Phospho-PP2A (pY307) antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue using anti-Phospho-PP2A (pY307) antibody. Counter stained with hematoxylin.
5. ICC staining Phospho-PP2A (pY307) in PC12 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
IP
推荐剂量
WB: 1:1000-5000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development. The core enzyme consists of catalytic C and regulatory A (or PR65) subunits, with each subunit represented by α and β isoforms. Additional regulatory subunits belong to four different families of unrelated proteins. Both the B (or PR55) and B' regulatory protein families contain α, β, γ and δ isoforms, with the B' family also including an ε protein. B'' family proteins include PR72, PR130, PR59 and PR48 isoforms, while striatin (PR110) and SG2NA (PR93) are both members of the B''' regulatory protein family. These B subunits competitively bind to a shared binding site on the core A subunit. This variable array of holoenzyme components, particularly regulatory B subunits, allows PP2A to act in a diverse set of functions. PP2A function is regulated by expression, localization, holoenzyme composition and post-translational modification. Phosphorylation of PP2A at Tyr307 by Src occurs in response to EGF or insulin and results in a substantial reduction of PP2A activity. Reversible methylation on the carboxyl group of Leu309 of PP2A has been observed. Methylation alters the conformation of PP2A, as well as its localization and association with B regulatory subunits.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human PP2A around the phosphorylation site of Tyr307
抗原种属
human
Uniprot ID
P62714
化学信息
分子量Theoretical: 35 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pPP2A (Y307)pPP2A (Tyr307)PP2A (pY307)PP2A (pTyr307)PP2A (phospho-Y307)PP2A (phospho-Tyr307)

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