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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-IRS1 Polyclonal Antibody

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货号 TMAB-00988

别名 IRS-1, Insulin receptor substrate 1

Anti-IRS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IRS1。Anti-IRS1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-IRS1 Polyclonal Antibody

Anti-IRS1 Polyclonal Antibody

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货号 TMAB-00988 别名 IRS-1, Insulin receptor substrate 1

Anti-IRS1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IRS1。Anti-IRS1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-IRS1 Polyclonal Antibody is a Rabbit antibody targeting IRS1. Anti-IRS1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名IRS-1, Insulin receptor substrate 1
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Pig,Cow,Horse,Rabbit,Sheep)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded Rat Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded Mouse Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with IRS1 Polyclonal Antibody, Unconjugated (TMAB-00988) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining.
verifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-300
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.
组织特异性Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vasc
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
抗原信息
免疫原
KLH conjugated synthetic peptide: rat IRS-1
抗原种属
Rat
基因名称
IRS1
基因ID
25467
蛋白名称
Insulin receptor substrate 1
Uniprot ID
P35570
研究领域
Tumor Associated,Insulin / Insulin-like,Cytoplasmic,Metabolism,Obesity,Heart disease,Diabetes,Cancer,Diabetes associated,Signal transduction
功能
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
化学信息
分子量Theoretical: 137 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

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