购物车
- 全部删除
您的购物车当前为空
Anti-HSP70 Antibody (5U116)
还可以产品编号 TMAH-00569
别名 HSX70, HSPA1, HSP72, HSP70I, HSP70-2, HSP70-1A, HSP70-1, HSP70.2, HSP70.1, HSP70, HEL-S-103
Anti-HSP70 Antibody (5U116) 是一种 Mouse 抗体，靶向 HSP70。Anti-HSP70 Antibody (5U116) 可用于 ELISA, WB。
Anti-HSP70 Antibody (5U116)
Anti-HSP70 Antibody (5U116)
还可以产品编号 TMAH-00569 别名 HSX70, HSPA1, HSP72, HSP70I, HSP70-2, HSP70-1A, HSP70-1, HSP70.2, HSP70.1, HSP70, HEL-S-103
Anti-HSP70 Antibody (5U116) 是一种 Mouse 抗体，靶向 HSP70。Anti-HSP70 Antibody (5U116) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-HSP70 Antibody (5U116) is a Mouse antibody targeting HSP70. Anti-HSP70 Antibody (5U116) can be used in ELISA, WB. |
| 别名 | HSX70, HSPA1, HSP72, HSP70I, HSP70-2, HSP70-1A, HSP70-1, HSP70.2, HSP70.1, HSP70, HEL-S-103 |
| Ig Type | IgG2a |
| 克隆号 | 5U116 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: Raji whole cell lysate, 293T whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, U87 whole cell lysate, A549 whole cell lysate -All lanes: HSPA1A antibody at 1:1000 -Secondary: Goat polyclonal to mouse IgG at 1/50000 dilution -Predicted band size: 71, 64 kDa -Observed band size: 71 kDa -Exposure time：5min |
| 应用 | ELISA, WB |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein G purified |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 纯度 | >95% |
| 研究背景 | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation. (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Heat shock 70 kDa Protein 1A Protein (291-641AA) |
| 抗原种属 | Human |
| 基因ID | 3303 |
| Uniprot ID | |
| 研究领域 | Signal Transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-HSP70 Antibody (5U116) | purchase Anti-HSP70 Antibody (5U116) | Anti-HSP70 Antibody (5U116) cost | order Anti-HSP70 Antibody (5U116)
嗨！有任何问题？点我咨询
评论内容