Anti-CD81 Antibody (9H76)

Name: Anti-CD81 Antibody (9H76)
Brand: TargetMol
SKU: TMAH-00224
Rating: 4.5 (1 reviews)

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产品编号 TMAH-00224

别名 TSPAN28, TAPA1, S5.7, CVID6, CD81 molecule

Anti-CD81 Antibody (9H76) 是一种 Mouse 抗体，靶向 CD81。Anti-CD81 Antibody (9H76) 可用于 ELISA, IHC。

Anti-CD81 Antibody (9H76)

还可以

产品编号 TMAH-00224 别名 TSPAN28, TAPA1, S5.7, CVID6, CD81 molecule

Anti-CD81 Antibody (9H76) 是一种 Mouse 抗体，靶向 CD81。Anti-CD81 Antibody (9H76) 可用于 ELISA, IHC。

规格	价格	库存	数量
50 μg	¥ 1,300	5日内发货
100 μg	¥ 2,180	5日内发货

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产品描述	Anti-CD81 Antibody (9H76) is a Mouse antibody targeting CD81. Anti-CD81 Antibody (9H76) can be used in ELISA, IHC.
别名	TSPAN28, TAPA1, S5.7, CVID6, CD81 molecule
Ig Type	IgG
克隆号	9H76
交叉反应	Human
验证活性	Immunohistochemical of paraffin-embedded Human tonsil tissue using TMAH-00224 at dilution of 1:200.
应用	ELISA, IHC
抗体种类	Monoclonal
宿主来源	Mouse
亚细胞定位	Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
构建方式	Hybridoma Monoclonal Antibody
纯化方式	Protein G purified
性状	Liquid
缓冲液	Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
纯度	>95%
研究背景	Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation. Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption. May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels. Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. (Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1. (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.