Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,820 | 5日内发货 | ||
5 mg | ¥ 2,890 | 5日内发货 | ||
10 mg | ¥ 4,160 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,780 | 5日内发货 |
产品描述 | Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase. |
体内活性 | In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2]. |
动物实验 | Rats: Lumicitabine is formulated as solutions in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 24 h post dose for rat [2]. Monkeys: Lumicitabine is formulated as a solution in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 12 h post dose for Monkeys [2]. |
别名 | ALS-8176, ALS-008176 |
分子量 | 433.86 |
分子式 | C18H25ClFN3O6 |
CAS No. | 1445385-02-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (110.63 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3049 mL | 11.5245 mL | 23.0489 mL | 57.6223 mL |
5 mM | 0.461 mL | 2.3049 mL | 4.6098 mL | 11.5245 mL | |
10 mM | 0.2305 mL | 1.1524 mL | 2.3049 mL | 5.7622 mL | |
20 mM | 0.1152 mL | 0.5762 mL | 1.1524 mL | 2.8811 mL | |
50 mM | 0.0461 mL | 0.2305 mL | 0.461 mL | 1.1524 mL | |
100 mM | 0.023 mL | 0.1152 mL | 0.2305 mL | 0.5762 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lumicitabine 1445385-02-3 Microbiology/Virology RSV ALS-8176 ALS8176 ALS 8176 ALS008176 ALS 008176 ALS-008176 Inhibitor inhibitor inhibit