Tetrazine-biotin is a cleavable linker vital in ADC synthesis. Tetrazine-biotin joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
Tetrazine-PEG4-biotin is a cleavable linker composed of a four-unit PEG (polyethylene glycol) chain. This compound is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs)[1].
Biotin-PEG3-Me-Tet, an ADC linker consisting of three PEG units, utilizes its Tetrazine group to participate in a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds containing TCO groups.