sprague-dawley

Ziprasidone hydrochloride (CP-88059 hydrochloride) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv在Sprague Dawley大鼠上进行测试时显示出高局部抗炎效力和高肺选择性。

Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) 在Sprague-Dawley 大鼠胃中组氨酸脱羧酶的抑制作用被评估为 14CO2 产生减少，活性值为 1.8 μM。

VPC171 是一种新型腺苷 A1 受体正变构调节剂 (PAM)。

Metyrapone (NSC-25265) 是 STEROID 11-BETA-MONOOXYGENASE 酶抑制剂。 它被用作库欣综合征诊断中下丘脑-垂体反馈机制的测试。

Treloxinate 是一种降血脂化合物，具有选择性作用。在 Sprague-Dawley 大鼠中，该化合物仅对甘油三酯水平显示出调节效果；然而，在 Wistar 大鼠中，它不仅调节甘油三酯水平，还能影响胆固醇水平。

MiADMSA（Monoisoamyl DMSA），一种亲脂性螯合剂，已显示出成为未来治疗砷及其他几种重金属（如铅、汞、镉和砷化镓）螯合剂 解毒剂的潜力。它能缓解钠钨酸引起的氧化应激，并改善慢性铜中毒在Sprague Dawley大鼠所引起的肝脏及免疫系统变化。此外，MiADMSA还能保护人类角质形成细胞‘HaCaT’免受砷引起的氧化应激。

Trimethylolpropane caprate has developmental toxicity in Sprague-Dawley rats.

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM[1]. Sepimostat (1 to 100 nmol eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. [1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.

Ensartinib(X-396)是一种有效和具有口服活性的ALK MET双重抑制剂，恩沙替尼可用于治疗ALK阳性的非小细胞肺癌(NSCLC)。

Neophytadiene 是一种可从 Turbinaria ornate 中提取到的二萜化合物，具有抗炎、抗抑郁、抗焦虑样、抗惊厥、抗氧化和心脏保护作用，抑制 RAW 264。7 巨噬细胞和 Sprague Dawley 大鼠中 LPS 诱导的炎症反应，可用于研究神经系统疾病。

NHE3-IN-3 (Compound 1) is a potent inhibitor of the isoform 3 of the Na+ H+ exchanger (NHE3). It exhibits pIC50 values of 6.2 and 6.6 against human and rat NHE3, respectively. Furthermore, NHE3-IN-3 showcases exceptional oral bioavailability of 98% in Sprague–Dawley rats [1].

The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine into the bloodstream in response to food and stimulate insulin secretion. GLP-1(7-37) produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in Sprague-Dawley Rats at a dosing rang of 0.5, 5, or 50 pmol min kg. Further, infusion of GLP-1(7-37) for 60 mins produced a small transitory increase in plasma insulin concentration in fasted rats and fed rats and a slight transitory decrease in plasma glucose concentration. Moreover, GLP-1(7-37) (5 pmol min kg IV) infusion for 6 h in Sprague-Dawley rats produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle[1].

DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.

Big endothelin-1 (rat 1-39) 是一个由39个氨基酸残基组成的多肽。它能在清醒状态的Sprague-Dawley大鼠中诱导利尿和利钠的反应，并可导致小鼠血压上升。

(+)-Osbeckic acid，一种Tartary Buckwheat中提取的血管松弛剂，对Sprague-Dawley大鼠胸主动脉环展现出显著的血管舒张效应，其半数有效浓度(EC50)为887 μM。

CK-963 是一种心肌肌钙蛋白(cTnC)的激活剂，Ki 为 11.5 μM，并能够增强 Sprague-Dawley 大鼠的心肌收缩力。

Triptolidepalmitate 是 Triptolide 的衍生物，对癌细胞 MCF-7 和 A549 具有细胞毒性，IC50 分别为 7.5 和 6.4 μM。在 Sprague Dawley 大鼠模型中的半衰期（T1 2）为 50.4 分钟。Triptolidepalmitate 可用作药物输送载体。

Myosin modulator 1 (Compound B141) 是一种肌球蛋白 (myosin) 调节剂，能够抑制兔腰大肌、猪心房及猪心室的 ATP 酶活性，其 IC25 分别为 0.42，0.13 和 3.09 μM。Myosinmodulator 1 还可以调节 Sprague Dawley 大鼠的心脏收缩功能。

Myosinmodulator 2 (Compound B172) 是一种肌球蛋白 (myosin) 调节剂，它能够抑制兔腰大肌、猪心房和猪心室的 ATP 酶，其 IC25 值分别为 2.013、2.94 和 20.93 μM。Myosinmodulator 2 可调节 Sprague Dawley 大鼠的心脏收缩性能。

GS-9770 是一种口服有效的HIV蛋白酶抑制剂，Ki为0.16 nM。它对HIV-1和HIV-2菌株显示出抗病毒活性，EC50分别为1.9-26 nM和26 nM。在人肝微粒体中，GS-9770 展现出代谢稳定性，并在Sprague-Dawley大鼠体内具有良好的药代动力学特征。

Recainam (Wy-42362) hydrochloride 是一种口服有效的抗心律失常药，具有 I 类电生理特性，可抑制复杂性室性心律失常。在 Sprague Dawley 大鼠中，Recainam hydrochloride 展示了良好的药代动力学特征。

Ajugasterone C shows significant inhibitory effect at 100 mg kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.

Eutypenes I (Compound 9) 能抑制VEGF-A的分泌、VEGFR的激活及其后续的Erk Akt信号通路。同时，Eutypenes I 可抑制HMEC-1细胞的迁移，并在Sprague-Dawley大鼠模型中展示出抗血管生成活性。