radical generation

Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) 是一种单胺氧化酶 B 的选择性的可逆抑制剂，但对 MAO-A 活性较低。它在高浓度时，具有抑制单胺摄取的作用，抑制去甲肾上腺素、血清素和多巴胺摄取。它可用于研究帕金森和阿尔茨海默病。

Lazabemide (Ro 19-6327) 是一种单胺氧化酶 B 的选择性的可逆抑制剂 ，但对 MAO-A 活性较低。它高浓度时具有抑制单胺摄取的作用，能够抑制去甲肾上腺素、血清素和多巴胺摄取，其IC50值分别为 86 μM、123 μM 和 >500 μM。它可用于研究帕金森和阿尔茨海默病。

AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions.

I2959 是一种广泛用于水凝胶光化学交联的光引发剂，与 CMA 水凝胶的结合已经成为生物 3D 打印应用中的生物墨水。除此之外，I2959 具备高效自由基生成能力，对快速分裂的细胞系表现出细胞毒性。

AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.[1],[2],[3],[4] Decomposition of AAPH produces molecular nitrogen and 2 carbon radicals. The carbon radicals may combine to produce stable products or react with molecular oxygen to give peroxyl radicals. The half-life of AAPH is about 175 hours (37°C at neutral pH), making the rate of free radical generation essentially constant during the first several hours in solution.[5] While AAPH may be used effectively for lipid peroxidation in aqueous dispersions of fatty acids, other radical generators may be better suited for peroxidation studies in lipid micelles or membranes.[6],[7]

N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) 是 Anandamide 的类似物。在沙鼠缺血再灌注模型中，N-Stearoyltyrosine 通过保护海马体 CA1 区显示出神经保护作用，并能抑制自由基的产生以及提高抗氧化能力。该化合物还可抑制 IR 诱导的细胞凋亡 (apoptosis)。