ptp1b-in-3

PTP1B-IN-3 是一种具有有选择性和高效性的 PTP1B 抑制剂，具有抗癌活性，抑制 PTP1B 和 TCPTP 。PTP1B-IN-3 可用于研究糖尿病。

PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent antidiabetic and anticancer properties, as supported by extensive research [1] [2].

PTP1B-IN-30 (Compound 3j) 是一种PTP1B抑制剂，其IC50为0.51 µM。PTP1B-IN-30 对癌细胞T47D的增殖具有抑制作用，IC50为21.21 µM，可导致细胞周期在S期停滞，并诱导T47D细胞凋亡 (apoptosis)。

PTP1B-IN-1 (PTP1B inhibitor) 是一种蛋白质酪氨酸磷酸酶 1B 的有效抑制剂 (IC50 : 1.6 mM)

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) 是一种磷脂酰乙醇胺，能提高恶性胸膜间皮瘤细胞的PP2A和PTP1B活性，并诱导NCI-H28恶性胸膜间皮瘤细胞凋亡 (apoptosis)。

MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively[1]. (A family of human MAPK-specific protein tyrosine phosphatases) [1]. Jeyanthy Eswaran, et al. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J. 2006 May 1;395(3):483-91.

SHP2-IN-29 (Compound 3), 一种SHP2抑制剂，展示出0.18 μM的IC50值。该化合物对PTP1B和TCPTP也具有抑制作用，其IC50值分别为4.27 μM和4.74 μM。

Cyanidin 3-arabinoside (Cyanidin 3-monoarabinoside) 是一种从蓝莓中提取的花青素，是选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，具有潜在的抗癌活性，可用于研究 2 型糖尿病。

5-O-Coumaroylquinic acid (3-O-Coumaroylquinic acid), exhibits significant inhibition of PTP1B and a concentration-dependent inhibitory effect on α-glucosidase, thereby demonstrating anti-hyperglycemic properties. Additionally, this compound enhances glucose uptake and inhibits PTP1B in vitro, emphasizing its potential therapeutic applications in glucose regulation.