pih

PIH is a ciliogenesis inhibitor by microtubule destabilization that acts by antagonizing Hh signaling by repressing cilia biogenesis and disassembly of alpha-tubulin in its stabilized form.

pyridoxal isonicotinoyl hydrazone (PIH) 是亲脂的三价铁螯合剂，具有高铁螯合特性。

Epihygromycin 是一种糖苷类抗生素，对革兰氏阳性菌表现出较弱的活性。

6-Epiharpagide is a natural product from Scrophularia ningpoensis Hemsl.

6-Epiharpagoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3167，CAS号为 1151862-67-7。

NDPIH，源自猴头菇（Hericium erinaceus），具有显著的神经营养活性，可在无血清的条件下促进培养的海马神经元中大量轴突生长和神经突触分支。尽管药理学上抑制肌动蛋白受体激酶B（TrkB）只能部分阻止NDPIH诱导的活性，NDPIH还是能独立于TrkB激活ERK1/2信号通路。

p-MPPI hydrochloride 是一种选择性的，具有高亲和力的5-HT1A 受体拮抗剂，能穿过血脑屏障，具有抗抑郁和抗焦虑样作用。

UCN-02 (7-epi-Hydroxystaurosporine) 是一种由链霉菌属 N-126 菌株产生，具有选择性和高效性的蛋白激酶 C (PKC) 抑制剂，抑制 PKA。UCN-02 具有抗肿瘤活性。

VU0360172 是 mGlu5 受体的正变构调节剂（EC50 = 16 nM；Ki = 195 nM）。

FIPI is an effective and selective phospholipase D inhibitor that reduces mercury-induced lipid signaling and thus protects aortic endothelial cells from cytotoxicity.

Potent positive allosteric modulator of α4β2 nAChRs (EC50 values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains. Hamouda (2016) Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (α4)3(β2)2 nAChR-selective positive allosteric modulator. Mol.Pharmacol. 89 575 PMID:26976945 |Albrecht et al (2008) Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators. Bioorg.Med.Chem.Lett. 18 5209 PMID:18789861 |Wang et al (2017) Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses. J.Biol.Chem. 292 9988 PMID:28446611

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.

8-epi-Helenalin是从旋复花根中提取的半萜内酯，具抗肿瘤活性。其对HL-60、A549、MCF7、HCT-15、SK-OV-3以及Malme-3M的(EC50)值分别是12.2 μM、53.8 μM、9.1 μM、8.7 μM、18.7 μM和8.3 μM。

2-Methyl-α-pyrrolidinoisohexanophenone (hydrochloride) (2-Methyl-α-PiHP (hydrochloride)) 是一种卡西酮类化合物。

VH-N412是一种载体化神经肽(NT)，能有效穿透血脑屏障。该化合物能同时与低密度脂蛋白受体(LDLR)及神经肽受体1(NTSR-1)结合，具有诱导药理性低体温(PIH)的能力。VH-N412不仅展现出抗惊厥效果，还具备神经保护功能，适用于探究癫痫等神经系统疾病。