octanoyl coenzyme a

Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.

Octanoyl coenzyme A triammonium 是一种酰基化形式的辅酶 A，属于中链类。此化合物针对柠檬酸合成酶 (citrate synthase) 及谷氨酸脱氢酶 (glutamate dehydrogenase) 显示出明显的抑制效果，其半抑制浓度（IC50）范围在 0.4至1.6 mM。

Octanoyl coenzyme A lithium 是一种脂肪酸酰基辅酶 A 的衍生物。Octanoyl coenzyme A lithium 能够抑制柠檬酸合成酶和谷氨酸脱氢酶 (IC50: 0.4-1.6 mM)。

1-Pyrenebutanoyl-CoA，作为一种辅酶A, 在大鼠肝脏线粒体中通过非竞争性机制 (Ki= 2 pM) 抑制磷酸化 (ADP 刺激) 的呼吸作用。此外，该化合物还能以竞争性方式 (Ki= 2.1 pM 和 15 pM) 抑制肉碱棕榈酰辅酶 A 转移酶和辛酰辅酶 A 转移酶。