nf-kappab-in-2

NF-κB-IN-2 抑制 PC-3细胞中 TNF-α诱导的的经典 NF-κB 信号传导。

5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT Nrf-2 HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。

Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。

Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。

SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.

Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱，具有抗炎活性。它通过抑制NF-κB 激活，剂量依赖性地抑制结肠癌细胞的增值和侵袭，并诱导凋亡。

MRS2693 trisodium，一种P2Y6选择性激动剂，其EC50为0.015 μM。该化合物能通过降低NF-kappaB激活及激活ERK1 2通路，在小鼠后肢骨骼肌缺血再灌注损伤模型中发挥细胞保护作用。

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant

Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg mL, respectively; it is active against tested Gram-positive bacteria, i

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).

Siegeskaurolic acid 是一种具有抗炎活性的天然产物。