mitoa

MitoA is a ratiometric mass spectrometry probe that can be used for assessing changes in H2S within mitochondria in vivo. MitoA contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its aryl azide moiety selectively reacts with H2S to produce an amine product, MitoN. Quantifying the MitoN MitoA ratio by LC-MS MS reflects the mitochondrial matrix H2S concentration. In a mouse model of acute myocardial infarction with MitoA administered prior to ischemia, the MitoN MitoA ratio is increased only in the region of ischemia.

Mito-apocynin (C2) is an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, has antineuroinflammatory effects.

Mito-apocynin (C11)是一种线粒体靶向抗氧化剂，通过靶向和中和细胞呼吸过程中产生的活性氧（ROS）发挥作用。三苯基溴化鏻已被发现能有效预防线粒体功能障碍，线粒体功能障碍是衰老过程和各种疾病的主要原因。它具有抗炎、抗凋亡和抗氧化活性。