ks-15

KS15 is a chemical compound that acts as an inhibitor on the interactions between cryptochromes, specifically CRY1 and CRY2, and the CLOCK: BMAL1 heterodimer. This compound, with an EC50 value of 4.9 μM, hinders the feedback actions of CRYs on E-box-dependent transcription. The CLOCK: BMAL1 heterodimer is a vital transcriptional regulator for the mammalian circadian clock. In addition, KS15 exhibits significant anti-proliferative activity.