d-9

TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR).

L-838417-D9是L-838417 (T19702)的氘代物。其中L-838417是亚型选择性GABAA 正变构调节剂，在 α2，α3 和 α5 亚型中作为部分激动剂。

Febuxostat-D9 is deuterium labeled Febuxostat,which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.

Nadolol-D9是Nadolol (T1203)的氘代物,其母本化合物 Nadolol (T1203)是一种可口服、非选择性的 β- 肾上腺素受体阻滞剂。

Valsartan-D9 is a deuterium-labeled valsartan. Valsartan (T6716) is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.

Desbutyl Lumefantrine-D9,a deuterium-labeled metabolite of Lumefantrine,exhibits the incorporation of deuterium atoms.

Ivacaftor-D9 is transmembrane conductance regulator (CFTR)channel activator,is used potentially for the treatment of cystic fibrosis.

Methyl-D9-choline is an isotopically labeled choline tracer.

Acetylcholine-D9 Chloride (Standard) 是 Acetylcholine-D9 Chloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Acetylcholine-d9(chloride) 是 Acetylcholine chloride 的氘代化合物。Acetylcholine chloride (ACh chloride) 是一种神经递质，也是有效的胆碱能激动剂。它通过刺激烟碱乙酰胆碱受体 (nAChRs) 来调节多巴胺能神经元的活性，并在体外抑制 p53 突变肽的聚集。

Pipecolic Acid-D9 (Standard) 是 Pipecolic Acid-D9 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pipecolic acid-d9是Pipecolic acid的氘代物。Pipecolic acid是赖氨酸的代谢产物和免疫调节剂，可促使植物产生系统获得性抗性(SAR)。它能够通过YAP-GPX4信号通路抑制糖尿病视网膜病变中的铁死亡(ferroptosis)，并可诱导神经细胞凋亡(apoptosis)。此外，Pipecolic acid还可作为吡哆醇依赖性癫痫的诊断标记。

Palmitic Acid-D9 (Standard) 是 Palmitic Acid-D9 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Palmitic acid-d9是Palmitic acid的氘代物。Palmitic acid是一种在动物和植物中常见的长链饱和脂肪酸，可引起小鼠颗粒细胞中葡萄糖调节蛋白78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Trimethoprim-D9 (Standard) 是 Trimethoprim-D9 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Trimethoprim-d9是Trimethoprim的氘代物。作为一种抑菌抗生素，Trimethoprim是具有口服活性的二氢叶酸还原酶 (dihydrofolate reductase) 抑制剂。Trimethoprim 对多种革兰氏阳性和革兰氏阴性需氧细菌 (Gram-positive和Gram-negative aerobic bacteria) 有效，并用于研究尿路感染、志贺氏菌病和肺孢子菌肺炎。

Coenzyme Q10-D9 (Standard) 是 Coenzyme Q10-D9 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Coenzyme Q10-d9 是 Coenzyme Q10 的氘代形式。Coenzyme Q10 在电子传递链中起着关键的辅助因子作用，并且具有强效的抗氧化性能。

Choline-D9 chloride是Choline chloride的氘代标记物，可用于同位素示踪。Choline chloride (T1039)是一种必需营养素，可激活α7烟碱受体，具有抗炎、镇痛的活性。

2-(5-tert-Butyl-2-hydroxyphenyl) benzotriazole-D9是2- (2H-Benzod][1,2,3]triazol-2-yl)-4- (tert-butyl)phenol 的氘代物。

SD-254 is a deuterium analog of Effexor,with fewer side effects and a longer half-life.

C-Met inhibitor D9 是一种c-Met 激酶抑制剂。

MDL-27048 is a powerful and reversible microtubule inhibitor.

Tebuconazole-D9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole (T17022) is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM,respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM)and is cytotoxic (EC20 = 38.9 µM)in an MDA-kb2 assay. Tebuconazole (T17022) (50 and 100 mg/kg per day)administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42,tebuconazole (20 and 60 mg/kg per day)leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning......

Guaifenesin-D3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin (T0739) is an expectorant. It inhibits production of mucin 5AC (MUC5AC),reduces mucus viscosity and elasticity,and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin (T0739)increases phenol red secretion,a marker of expectorant activity,in rats.3 Formulations containing guaifenesin have been used as expectorants in the treatment of the common cold and chronic bronchitis.

Phenylbutazone-D9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone (T1432) is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (T1432) (2 mg/kg)reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis. Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

G-33378 is a metabolite of sulfinpyrazone that inhibits human platelet cyclo-oxygenase activity.

1,3,7-Trimethyluric Acid-D9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.

hClpP-activator-D9 is a novel potent and species-selective activator of human ClpP (hClpP).