cn 1

Carnostatine hydrochloride (SAN9812 hydrochloride) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的Ki 值为 11 nM。Carnostatine hydrochloride 可用于治疗糖尿病性肾病 (DN) 。

αs1-CN f(143–149) 是一种酪蛋白衍生的肽序列,具备口服活性.该化合物显示出血管紧张素转换酶 (ACE) 的抑制效果(IC50=6.58 μM),并具有抗高血压活性.

Carnostatine (SAN9812) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的Ki 值为 11 nM。Carnostatine 可用于治疗糖尿病性肾病 (DN) 。

DCN 179177 is biochemical.

Ribavirin (Tribavirin) 是一种合成的呋喃核苷类似物，一种抗病毒剂。Ribavirin 具有抗丙型肝炎病毒和其他 RNA 病毒的活性。

RO-275 是一种具有口服活性和选择性的 HCN1 抑制剂，抑制 HCN2、HCN3、HCN4，挽救工作记忆减退，可用于研究认知障碍。

CN128 hydrochloride 是一种CN128衍生物，是一种具有口服活性和选择性的铁螯合剂。CN128是一种新型且具有口服活性的羟吡啶酮铁螯合剂，可用于研究 β-地中海贫血。

TC-N 1752 是一种具有口服活性的 Nav1.7 通道抑制剂，IC50 为 0.17 μM。 TC-N 1752 显示镇痛活性。

DCN1-UBC12-IN-4 （compound 5p）是一种DCN1-UBC12的抑制剂，表现出抗肿瘤活性，其IC50值超过10000 nM。

WS-383 free base is a selective and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).

Anti-B7-H4 VTCN1 Antibody 是一种通过 CHO 表达的人源抗体，专门靶向 B7-H4 VTCN1。它具有 huIgG1 型重链和 huκ 型轻链，预测分子量 (MW) 为 145 kDa。关于同型对照，建议参考 HumanIgG1kappa, Isotype Control。

Abrusoside A is an inhibitor of hACE2

DCN1-UBC12-IN-1 是有效的、特异性的 DCN1-UBC12 抑制剂，其 IC50 值为 2.86 nM，具有抗心脏成纤维化活性。

WS-383 是高效、选择性、可逆的DCN1-UBC12相互作用抑制剂，IC50为11 nM。它抑制 Cul3 1 的类泛素化修饰，引起 NRF2，p21和p27 的积累。

Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone production, steroid hormones being synthesized from cholesterol.

Oxybutynin R-isomer , also known as Aroxybutynin, is a muscarinic receptor antagonist. Aroxybutynin is the optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects).

NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。

DCN1-IN-2，作为一种DCN1抑制剂，具有2.96 nM的IC50值。该化合物能有效抑制Ang II TGFβ引起的心脏成纤维细胞活化，并通过选择性地抑制cullin 3，减轻ISO诱发的小鼠心脏纤维化及心脏重塑。

Spectramide is a dopamine D-2 receptor antagonist.

KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner. KCN1 potently inhibited the growth of subcutaneous malignant glioma tumor xenografts with minimal adverse effects on the host.

Anti-CYR61 CCN1 Antibody 是一种由 CHO 表达的人源抗体，专门靶向 CYR61 CCN1。其重链为 huIgG1 型，轻链为 huκ 型，预测分子量 (MW) 为 150 kDa。Anti-CYR61 CCN1 Antibody 的同型对照请参见 HumanIgG1kappa, Isotype Control。

CN128, an orally bioavailable iron chelator, features a side chain hydroxy group serving as an alternate sacrificial glucuronidation site to mitigate metabolic inactivation at the 3-hydroxy group. When administered at doses of 150 and 450 µmol kg, CN128 enhances iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload.

DCN1-UBC12-IN-2 是有效的、特异性的 DCN1-UBC12 抑制剂，其 IC50 值为 9.55 nM。DCN1-UBC12-IN-2 能够特异性靶向 DCN1-UBC12 相互作用，减缓 Ang II 诱导的心脏成纤维细胞活化。

Mefenamic acid (CN-35355) 是一种非甾体抗炎剂，可竞争性抑制hCOX-1和hCOX-2，IC50值分别为 40 nM 和 3 μM。