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cholesterol myristate

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    TargetMol | Inhibitors_Agonists
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    TargetMol | Natural_Products
  • Cholesterol myristate
    胆甾烯基豆蔻酸酯, 胆固醇肉豆蔻酸, Cholesteryl tetradecanoate, Cholesteryl myristate
    T80401989-52-2
    Cholesterol myristate (Cholesteryl myristate) 是粗吻海龙中的一种类固醇,可与多种离子通道结合,例如nAChR、GABAA 受体和内向整流钾离子通道。
    • ¥ 108
    现货
    规格
    数量
    TargetMol | Inhibitor Sale
  • Betulonaldehyde
    T692444439-98-9
    Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg ml, respectively). Topical application of betulonaldehyde (1 mg ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives.
    • ¥ 2760
    35日内发货
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    数量
  • Lyso-Globotriaosylceramide (d18:1)
    Lyso-Globotriaosylceramide (d18:1)
    T37291126550-86-5
    Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. It also accumulates in the urine, kidney, and plasma of patients with Fabry disease. Lyso-globotriaosylceramide levels decrease in response to administration of the α-galactosidase inhibitor 1-deoxygalactonojirimycin in a transgenic mouse model of Fabry disease. Decreases in plasma and urine concentrations of lyso-globotriaosylceramide have been used as a biomarker for efficacy of enzyme replacement therapy (ERT) and other therapies in the treatment of Fabry disease.
    • 待估
    35日内发货
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  • C2 L-threo Ceramide (d18:1/2:0)
    C2 L-threo Ceramide (d18:1 2:0)
    T35927143615-69-4
    C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0 G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.
    • ¥ 2417
    期货
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    数量
  • 7β,27-dihydroxy cholesterol
    7β,27-dihydroxy Cholesterol, 7β,27-DHC
    T36998240129-43-5
    7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .
    • 待估
    35日内发货
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