antibacterial agent 28

Antibacterial agent 28, with a minimum inhibitory concentration (MIC) range of 0.5-2 μg mL, exhibits promising potential as an antibacterial candidate targeting MRSA infections.

Antibacterialagent 169 (Compound 28) 作为一种吡咯酰胺型 GyrB ParE 抑制剂，呈现出对Staphylococcus aureus的 Gyrase 和 Topo IV 的选择性抑制作用，其IC50值分别为49 nmol L和1.513 μmol L，表明其具有显著的抗菌活性。