Atorvastatin acetonide tert-butyl ester, a valuable pharmaceutical intermediate, is used in preparing Atorvastatin salts, an HMG-CoA reductase inhibitor.
Atorvastatin acetonide is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
6',7'-Dihydroxybergamottin is a potent inhibitor of CYP3A activity, and may be primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans.
Remdesivir O-desphosphate acetonide impurity is a contaminant found in Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue known for its potent antiviral properties, particularly in inhibiting SARS-CoV-2 (COVID-19) infection in vitro.