a 1(i) collagen , human

This is a peptide inhibitor of collagen fibrillar matrix assembly.

ALK5-IN-82 是一种激活素受体样激酶 5 (ALK5) 的高选择性抑制剂，其IC50值仅为 9.1 nM。该化合物能够有效抑制转化生长因子-β 在人脐静脉内皮细胞中诱导的 α-平滑肌肌动蛋白 (α-SMA)、胶原蛋白 I 以及金属蛋白酶抑制剂 1 (TIMP-1) 和基质金属蛋白酶 13 (MMP‐13) 的表达。因此，ALK5-IN-82 有潜力应用于心脏纤维化的相关研究。

Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS has been detected in anti-wrinkle creams.4 |1. Choi, Y.L., Park, E.J., Kim, E., et al. Dermal stability and in vitro skin permeation of collagen pentapeptides (KTTKS and palmitoyl-KTTKS). Biomol. Ther. (Seoul) 22(4), 321-327 (2014).|2. Jones, R.R., Castelletto, V., Connon, C.J., et al. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol. Pharm. 10(3), 1063-1069 (2013).|3. Castelletto, V., Hamley, I.W., Whitehouse, C., et al. Self-assembly of palmitoyl lipopeptides used in skin care products. Langmuir 29(29), 9149-9155 (2013).|4. Chirita, R.-I., Chaimbbault, P., Archambault, J.-C., et al. Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics. Anal. Chim. Acta 641(1-2), 95-100 (2009).

Angiotensin II human TFA 是肾素-血管紧张素系统中的强效血管收缩剂，通过与 AT1R 和 AT2R 受体作用调节血压，可激活交感神经、促进醛固酮合成和肾功能，诱导血管平滑肌细胞增殖及成纤维细胞中 I 型和 III 型胶原合成，导致血管和心肌增厚、纤维化，并诱导凋亡及促进毛细血管生成，可用于构建心脏肥大、高血压和腹主动脉瘤模型。

H-Gly-Pro-Hyp-OH是一种有效和可口服的抗光老化胶原肽，能够减轻炎症，降低MMP-1和MMP-3含量；能够减轻H2O2诱导的真皮成纤维细胞老化；能够恢复皮质醇介导的I型胶原蛋白和GR激活的抑制和(TGF)-β信号等抑制；改善人体皮肤的水合性、弹性和抗皱性。