Eicosadienoic acid

Eicosadienoic acid 是天然存在的 n-6 多不饱和脂肪酸，主要再动物组织中获得。

11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid , a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5'-monophosphate dehydrogenase (Ki = 3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance. Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.

8(Z),14(Z)-Eicosadienoic Acid, an ω-8 C20:2 fatty acid, constitutes 0.19% of total fatty acids in human milk. In vivo, it is converted by desaturases into eicosatrienoic acids, known for their potent vasodilator properties. However, the physiological effects of 8(Z),14(Z)-Eicosadienoic Acid remain unexplored.

11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.

12,15-Epoxy-13-methyl-12,14-eicosadienoic acid, a furan fatty acid first identified in northern pike (E. lucius), exhibits elevated levels in the liver of starving cod.

7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) 显著影响了 βA(25-35) 所触发的生物反应。此化合物能有效减少 ROS 的生成。

11(Z),14(Z)-Eicosadienoic acid（11(Z),14(Z)-二十碳二烯酸）是一种不饱和脂肪酸和代谢物，能够抑制[3H]LTB4与中性粒细胞模的结合(Ki=3 μm)。

cis-9,12-Eicosadienoic acid 一种在生化反应中使用的试剂。

12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms.

(±)15-HEDE is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid. There are no reports in the literature of biological activity associated with (±)15-HEDE.

15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 μM.

15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Cat. No. 44720).

(±)11-HEDE, a racemic mixture comprising the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE, is synthesized from eicosadienoic acid via cyclooxygenase (COX) activity and within macrophages.

11(R)-HEDE is synthesized from 11Z,14Z-eicosadienoic acid through a lipoxygenase-type reaction mediated by COX. Spectrophotometric analysis, specifically measuring the absorbance of the conjugated diene in 11(R)-HEDE, serves as an occasional method for quantifying COX activity.