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IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc)

产品编号 TMPY-05839

IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.84 kDa and the accession number is P59822-1.

IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc)

产品编号 TMPY-05839

IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.84 kDa and the accession number is P59822-1.

规格	价格	库存
5 μg	¥ 492	6-8日内发货
10 μg	¥ 785	6-8日内发货
20 μg	¥ 1,320	6-8日内发货
50 μg	¥ 2,620	6-8日内发货
100 μg	¥ 4,430	6-8日内发货

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产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.84 kDa and the accession number is P59822-1.
种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P59822-1
别名	interleukin 1 receptor accessory protein
蛋白构建	A DNA sequence encoding the cynomolgus IL1RAP (NP_001028132.1) (Met1-Glu359) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ser 21
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	65.84 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.