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IL-15 & IL-15RA Protein, Human, Recombinant (hFc)

产品编号 TMPY-06020

IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.

IL-15 & IL-15RA Protein, Human, Recombinant (hFc)

产品编号 TMPY-06020

IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.

规格	价格	库存
5 μg	¥ 638	6-8日内发货
10 μg	¥ 1,050	6-8日内发货
20 μg	¥ 1,750	6-8日内发货
50 μg	¥ 3,470	6-8日内发货
100 μg	¥ 5,880	6-8日内发货
200 μg	¥ 9,870	6-8日内发货
500 μg	¥ 21,800	6-8日内发货
1 mg	¥ 38,500	6-8日内发货

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产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.
种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	NP_002180.1&NP_000576.1
蛋白构建	A DNA sequence encoding the human IL15RA (NP_002180.1) (Ile31-Asp96) linked with the human IL15 (NP_000576.1, with mutation Asn 120 Asp) (Asn49-Ser162) by a peptide linker was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ile 31
蛋白纯度	> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC.
分子量	47.9 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mMTris, 100 mMNacl, 5%trehalose, 0.05%chaps, pH8.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL-15 and IL-15 receptor alpha (IL-15Rα) play a significant role in multiple aspects of T cell biology. Interleukin (IL)-15 is essential for natural killer (NK), NKT and memory (m) CD8+ T cell development and function, and is currently under investigation as an immunotherapeutic agent for the treatment of cancer. Recently, the creation of IL-15 superagonist by complexing IL-15 and its high affinity receptor alpha (IL-15 Rα) in solution, inspired by the natural trans-presentation of IL-15, advances the potential of IL-15-based tumor immunotherapy. Gene therapy using engineered cells co-expressing IL-15/IL-15 Rα complex for cancer treatment is also emerging.