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Search Results for " telomerase "

Targets Recommended: Telomerase Telomerase

28

抑制剂 & 化合物

7

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13115	Telomerase-IN-2 Telomerase inhibitor 2,端粒酶抑制剂2	Telomerase	DNA Damage/DNA Repair
	Telomerase-IN-2 (Telomerase inhibitor 2) 是一种端粒酶抑制剂，通过降低角化不良蛋白的表达来抑制其活性，IC50值为 0.89 µM，具有抗癌作用。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T41290	MST-312 Telomerase Inhibitor IX	Telomerase	DNA Damage/DNA Repair
	MST-312 (Telomerase Inhibitor IX) 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的衍生物。MST-312 是 telomerase 抑制剂，可用于肿瘤的研究，如多发性骨髓瘤 (MM)。
T13116	Telomerase-IN-3	Others	Others
	Telomerase-IN-3 is an inhibitor of telomerase.
T72789	Telomerase-IN-4	Apoptosis	Apoptosis
	Telomerase-IN-4为高效的telomerase抑制剂，展现出抗增殖特性并能诱导apoptosis。
T72790	Telomerase-IN-5	Apoptosis	Apoptosis
	Telomerase-IN-5 是一种端粒酶抑制剂，表现出显著的抗增殖活性并能诱导细胞凋亡。
T2380	BIBR 1532	Apoptosis; Telomerase	Apoptosis; DNA Damage/DNA Repair
	BIBR 1532 是一种选择性端粒酶非竞争性抑制剂，IC50值为 100 nM。
T7409	360A 3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓]	DNA/RNA Synthesis; Telomerase	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	360A 是一种稳定的G-四链体配体，还抑制 TRAP-G4 试验中端粒酶的端粒酶活性，IC50值为 300 nM。
T13174	TMPyP4 tosylate TMP 1363	DNA/RNA Synthesis; Telomerase	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	TMPyP4 tosylate (TMP 1363) 是四链体 (G-quadruplex) 的特异性配体，抑制四链体和 IGF-1 之间的相互作用。它也是端粒酶抑制剂，在骨肉瘤细胞系中显示抗肿瘤作用。
T6133	Remodelin hydrobromide Remodelin,Remodelin HBR	RAAS; Histone Acetyltransferase	Chromatin/Epigenetic; Endocrinology/Hormones
	Remodelin hydrobromide (Remodelin HBR) 是一种新型有效的选择性乙酰转移酶蛋白 NAT10 抑制剂，能改善早衰综合征细胞表型。
T10760	Ceramides Mixture 神经酰胺混合物,神经酰胺	Telomerase	DNA Damage/DNA Repair
	Ceramides Mixture 是表皮渗透屏障的主要脂质成分，参与生长抑制，细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。
T8647	BCH001	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BCH001 是喹啉衍生物，是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。
T6967	RHPS4 RHPS 4 methosulfate,NSC714187	Apoptosis; Telomerase	Apoptosis; DNA Damage/DNA Repair
	RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。
T1267	Abacavir Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。
T6367	Abacavir sulfate Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂，可用于 HIV 和 AIDS。
T23819	Braco-19 trihydrochloride BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl	Telomerase	DNA Damage/DNA Repair
	Braco-19 trihydrochloride (BRACO19 3HCl) 是一种端粒酶抑制剂，可阻止端粒酶的加帽和催化作用。 Braco-19 trihydrochloride 抑制 HAdV 病毒复制。
T6746	6-Thio-2'-Deoxyguanosine 6-Thio-dG,β-TGdR	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	6-Thio-2'-Deoxyguanosine (β-TGdR) 是一种核苷类似物和端粒酶底物，可以通过端粒酶掺入重新合成的端粒中。
TP1291	Epithalon TFA (307297-39-8 free base) Epithalon TFA	Others	Others
	Epithalon TFA (307297-39-8 free base) (Epithalon TFA) 是一种抗衰老剂和端粒酶激活剂。
T10574	BMVC	Telomerase	DNA Damage/DNA Repair
	BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).
T13504	360A iodide 360 A iodide	Telomerase	DNA Damage/DNA Repair
	360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).
T33157	Macrocalin B
	Macrocalin B is a diterpenoid against tumor cell proliferation and telomerase activity.
T25207	CAUE
	CAUE is a telomerase activity inhibitor in NALM-6 human B-cell leukemia cells.
T26872	BMVC4 BMVC 4,BMVC-4
	BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
T28942	Telomestatin SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95
	Telomestatin is an inhibitor of the telomerase, it induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region.
T83248	7-Deaza-2′-deoxyguanosine 5′-triphosphate 7-Deaza-2'-dGTP	Telomerase	DNA Damage/DNA Repair
	7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP)为核苷酸类似物，兼具端粒酶抑制活性(IC50为11μM)。
T61679	Abacavir monosulfate
	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
T73264	L2H2-6OTD
	L2H2-6OTD, 为含有一至四个G-四联体结合环的端粒抑制素类似物，显示出对端粒酶 (telomerase) 的抑制活性，其IC50值达到15 nM。
T35428	β-Rubromycin
	β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 μM. It also has antibacterial activity against Gram-positive bacteria. The structure of β-rubromycin was originally described as containing an ortho-quinone group,...

化合物

Telomerase-IN-2

Cat.No: T13115

Synonym: Telomerase inhibitor 2,端粒酶抑制剂2

Target: Telomerase

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

Cat.No: T41290

Synonym: Telomerase Inhibitor IX

Target: Telomerase

Telomerase-IN-3

Cat.No: T13116

Target: Others

Telomerase-IN-4

Cat.No: T72789

Target: Apoptosis

Telomerase-IN-5

Cat.No: T72790

Target: Apoptosis

Cat.No: T2380

Target: Apoptosis, Telomerase

Cat.No: T7409

Synonym: 3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓]

Target: DNA/RNA Synthesis, Telomerase

TMPyP4 tosylate

Cat.No: T13174

Synonym: TMP 1363

Target: DNA/RNA Synthesis, Telomerase

Remodelin hydrobromide

Cat.No: T6133

Synonym: Remodelin,Remodelin HBR

Target: RAAS, Histone Acetyltransferase

Ceramides Mixture

Cat.No: T10760

Synonym: 神经酰胺混合物,神经酰胺

Target: Telomerase

Cat.No: T8647

Target: DNA/RNA Synthesis

Cat.No: T6967

Synonym: RHPS 4 methosulfate,NSC714187

Target: Apoptosis, Telomerase

Cat.No: T1267

Synonym: Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Abacavir sulfate

Cat.No: T6367

Synonym: Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Braco-19 trihydrochloride

Cat.No: T23819

Synonym: BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl

Target: Telomerase

6-Thio-2'-Deoxyguanosine

Cat.No: T6746

Synonym: 6-Thio-dG,β-TGdR

Target: Others, DNA/RNA Synthesis

Epithalon TFA (307297-39-8 free base)

Cat.No: TP1291

Synonym: Epithalon TFA

Target: Others

Cat.No: T10574

Target: Telomerase

Cat.No: T13504

Synonym: 360 A iodide

Target: Telomerase

Cat.No: T33157

Cat.No: T25207

Cat.No: T26872

Synonym: BMVC 4,BMVC-4

Cat.No: T28942

Synonym: SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95

7-Deaza-2′-deoxyguanosine 5′-triphosphate

Cat.No: T83248

Synonym: 7-Deaza-2'-dGTP

Target: Telomerase

Abacavir monosulfate

Cat.No: T61679

Cat.No: T73264

Cat.No: T35428

Cat. No.	Product Name	Target	Signaling Pathways
T5575	Cycloastragenol 环黄芪醇,Cyclogalegenol,Astramembrangenin	Epigenetic Reader Domain; Telomerase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Cycloastragenol (Astramembrangenin) 是一种三萜皂苷类化合物，是黄芪主要活性成分的水解产物，具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂，可以延长端粒，还能缓解与年龄相关的骨丢失，改善骨微结构和生物力学特性。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T6S0052	Chelerythrine Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine	Apoptosis; BCL; PKC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling
	Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。
TN1059	Ganoderic acid B	IL Receptor; HIV Protease; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂，抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
T2988	(-)-Epigallocatechin Gallate Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG	Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	(-)-Epigallocatechin Gallate (EGCG) 是茶类黄酮，具有强大的抗氧化，抗炎和抗癌作用。它可抑制EGFR 信号传导，有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。
T2902	Costunolide Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯	Apoptosis; Endogenous Metabolite; Telomerase	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。
T27282	Erucin AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056
	Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-induced neurodegenration, and inhib

天然产物

Cycloastragenol

Cat.No: T5575

Synonym: 环黄芪醇,Cyclogalegenol,Astramembrangenin

Target: Epigenetic Reader Domain, Telomerase

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Cat.No: T6S0052

Synonym: Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Ganoderic acid B

Cat.No: TN1059

Target: IL Receptor, HIV Protease, JAK, STAT

(-)-Epigallocatechin Gallate

Cat.No: T2988

Synonym: Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Cat.No: T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Target: Apoptosis, Endogenous Metabolite, Telomerase

Cat.No: T27282

Synonym: AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00452	SBDS Protein, Mouse, Recombinant (His) 4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s...	Mouse	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.
TMPH-02926	TRET Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de...
TMPH-02186	TERT Protein, Human, Recombinant (His)	Human	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de...
TMPH-02185	TEP1 Protein, Human, Recombinant (His)	Human	E. coli
	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
TMPY-00518	SBDS Protein, Human, Recombinant (His) CGI-97,Shwachman-Bodian-Diamond syndrome,SDS,SWDS	Human	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.
TMPJ-01357	NHP2 Protein, Human, Recombinant (His) NOLA2,Nucleolar protein family A member 2,snoRNP protein NHP...	Human	E. coli
	NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein particle with GAR1 (NOLA1). NHP2 is involved in a variety of aspects of rRNA processing and modification. NHP2 localizes to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies. NHP2 may also be required for correct processing or intranuclear trafficking of TERC...
TMPH-01089	CBX7 Protein, Human, Recombinant (His) Chromobox protein homolog 7,CBX7	Human	E. coli
	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in hi...
TMPH-01833	Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)	HPV 16	Yeast
	Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several...
TMPH-01832	Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)	HPV 16	E. coli
	Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several...

重组蛋白

SBDS Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00452

Species: Mouse

Expression System: E. coli

TRET Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02926

Species: Mouse

Expression System: E. coli

TERT Protein, Human, Recombinant (His)

Cat.No: TMPH-02186

Species: Human

Expression System: E. coli

TEP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02185

Species: Human

Expression System: E. coli

SBDS Protein, Human, Recombinant (His)

Cat.No: TMPY-00518

Species: Human

Expression System: E. coli

NHP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01357

Species: Human

Expression System: E. coli

CBX7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01089

Species: Human

Expression System: E. coli

Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)

Cat.No: TMPH-01833

Species: HPV 16

Expression System: Yeast

Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)

Cat.No: TMPH-01832

Species: HPV 16

Expression System: E. coli

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