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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13115 |
Telomerase-IN-2
Telomerase inhibitor 2,端粒酶抑制剂2 |
Telomerase | DNA Damage/DNA Repair |
Telomerase-IN-2 (Telomerase inhibitor 2) 是一种端粒酶抑制剂,通过降低角化不良蛋白的表达来抑制其活性,IC50值为 0.89 µM,具有抗癌作用。 | |||
T12009 |
Telomerase-IN-1
|
Telomerase | DNA Damage/DNA Repair |
Telomease-IN-1是一种端粒酶抑制剂(IC50:0.19μM)。Telomease-IN-1通过ER 过度反应(EOR)的内质网应激(ERS)激活hTERT 的表达,然后诱导ERS,导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP(CAAT /增强子结合蛋白同源蛋白))和线粒体凋亡途径,导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性,对SMMC-7721细胞具有较高的抗增殖能力,对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。 | |||
T41290 |
MST-312
Telomerase Inhibitor IX |
Telomerase | DNA Damage/DNA Repair |
MST-312 (Telomerase Inhibitor IX) 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的衍生物。MST-312 是 telomerase 抑制剂,可用于肿瘤的研究,如多发性骨髓瘤 (MM)。 | |||
T13116 |
Telomerase-IN-3
|
Others | Others |
Telomerase-IN-3 is an inhibitor of telomerase. | |||
T72789 |
Telomerase-IN-4
|
Apoptosis | Apoptosis |
Telomerase-IN-4为高效的telomerase抑制剂,展现出抗增殖特性并能诱导apoptosis。 | |||
T72790 | Telomerase-IN-5 | Apoptosis | Apoptosis |
Telomerase-IN-5 是一种端粒酶抑制剂,表现出显著的抗增殖活性并能诱导细胞凋亡。 | |||
T2380 |
BIBR 1532
|
Apoptosis; Telomerase | Apoptosis; DNA Damage/DNA Repair |
BIBR 1532 是一种选择性端粒酶非竞争性抑制剂,IC50值为 100 nM。 | |||
T7409 |
360A
3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓] |
DNA/RNA Synthesis; Telomerase | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
360A 是一种稳定的G-四链体配体,还抑制 TRAP-G4 试验中端粒酶的端粒酶活性,IC50值为 300 nM。 | |||
T13174 |
TMPyP4 tosylate
TMP 1363 |
DNA/RNA Synthesis; Telomerase | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TMPyP4 tosylate (TMP 1363) 是四链体 (G-quadruplex) 的特异性配体,抑制四链体和 IGF-1 之间的相互作用。它也是端粒酶抑制剂,在骨肉瘤细胞系中显示抗肿瘤作用。 | |||
T6133 |
Remodelin hydrobromide
Remodelin,Remodelin HBR |
RAAS; Histone Acetyltransferase | Chromatin/Epigenetic; Endocrinology/Hormones |
Remodelin hydrobromide (Remodelin HBR) 是一种新型有效的选择性乙酰转移酶蛋白 NAT10 抑制剂,能改善早衰综合征细胞表型。 | |||
T10760 |
Ceramides Mixture
神经酰胺混合物,神经酰胺 |
Telomerase | DNA Damage/DNA Repair |
Ceramides Mixture 是表皮渗透屏障的主要脂质成分,参与生长抑制,细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺,由含羟基和非羟基脂肪酸的神经酰胺组成。 | |||
T8647 |
BCH001
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BCH001 是喹啉衍生物,是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。 | |||
T6967 |
RHPS4
RHPS 4 methosulfate,NSC714187 |
Apoptosis; Telomerase | Apoptosis; DNA Damage/DNA Repair |
RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂,是一种有效的亚微摩尔端粒酶抑制剂,IC50为0.33 μM。 | |||
T1267 |
Abacavir
Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate |
Apoptosis; HIV Protease; Reverse Transcriptase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。 | |||
T6367 |
Abacavir sulfate
Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen |
Apoptosis; HIV Protease; Reverse Transcriptase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂,可用于 HIV 和 AIDS。 | |||
T23819 |
Braco-19 trihydrochloride
BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl |
Telomerase | DNA Damage/DNA Repair |
Braco-19 trihydrochloride (BRACO19 3HCl) 是一种端粒酶抑制剂,可阻止端粒酶的加帽和催化作用。 Braco-19 trihydrochloride 抑制 HAdV 病毒复制。 | |||
T6746 |
6-Thio-2'-Deoxyguanosine
6-Thio-dG,β-TGdR |
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
6-Thio-2'-Deoxyguanosine (β-TGdR) 是一种核苷类似物和端粒酶底物,可以通过端粒酶掺入重新合成的端粒中。 | |||
TP1291 |
Epithalon TFA (307297-39-8 free base)
Epithalon TFA |
Others | Others |
Epithalon TFA (307297-39-8 free base) (Epithalon TFA) 是一种抗衰老剂和端粒酶激活剂。 | |||
T10574 |
BMVC
|
Telomerase | DNA Damage/DNA Repair |
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM). | |||
T13504 |
360A iodide
360 A iodide |
Telomerase | DNA Damage/DNA Repair |
360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay). | |||
T33157 |
Macrocalin B
|
||
Macrocalin B is a diterpenoid against tumor cell proliferation and telomerase activity. | |||
T25207 |
CAUE
|
||
CAUE is a telomerase activity inhibitor in NALM-6 human B-cell leukemia cells. | |||
T26872 |
BMVC4
BMVC 4,BMVC-4 |
||
BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity. | |||
T28942 |
Telomestatin
SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95 |
||
Telomestatin is an inhibitor of the telomerase, it induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. | |||
T83248 |
7-Deaza-2′-deoxyguanosine 5′-triphosphate
7-Deaza-2'-dGTP |
Telomerase | DNA Damage/DNA Repair |
7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP)为核苷酸类似物,兼具端粒酶抑制活性(IC50为11μM)。 | |||
T61679 |
Abacavir monosulfate
|
||
Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3]. | |||
T73264 | L2H2-6OTD | ||
L2H2-6OTD, 为含有一至四个G-四联体结合环的端粒抑制素类似物,显示出对端粒酶 (telomerase) 的抑制活性,其IC50值达到15 nM。 | |||
T35428 |
β-Rubromycin
|
||
β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 μM. It also has antibacterial activity against Gram-positive bacteria. The structure of β-rubromycin was originally described as containing an ortho-quinone group,... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5575 |
Cycloastragenol
环黄芪醇,Cyclogalegenol,Astramembrangenin |
Epigenetic Reader Domain; Telomerase | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Cycloastragenol (Astramembrangenin) 是一种三萜皂苷类化合物,是黄芪主要活性成分的水解产物,具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂,可以延长端粒,还能缓解与年龄相关的骨丢失,改善骨微结构和生物力学特性。 | |||
T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
T6S0052 |
Chelerythrine
Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine |
Apoptosis; BCL; PKC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling |
Chelerythrine (Broussonpapyrine) 是一种天然生物碱,为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂,IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合,IC50为 1.5 μM,并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。 | |||
TN1059 |
Ganoderic acid B
|
IL Receptor; HIV Protease; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂,抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。 | |||
T2988 |
(-)-Epigallocatechin Gallate
Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG |
Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
(-)-Epigallocatechin Gallate (EGCG) 是茶类黄酮,具有强大的抗氧化,抗炎和抗癌作用。它可抑制EGFR 信号传导,有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。 | |||
T2902 |
Costunolide
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯 |
Apoptosis; Endogenous Metabolite; Telomerase | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。 | |||
T27282 |
Erucin
AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056 |
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Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-induced neurodegenration, and inhib |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00452 |
SBDS Protein, Mouse, Recombinant (His)
4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s... |
Mouse | E. coli |
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. | |||
TMPH-02926 |
TRET Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de... | |||
TMPH-02186 |
TERT Protein, Human, Recombinant (His)
|
Human | E. coli |
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de... | |||
TMPH-02185 |
TEP1 Protein, Human, Recombinant (His)
|
Human | E. coli |
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. | |||
TMPY-00518 |
SBDS Protein, Human, Recombinant (His)
CGI-97,Shwachman-Bodian-Diamond syndrome,SDS,SWDS |
Human | E. coli |
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. | |||
TMPJ-01357 |
NHP2 Protein, Human, Recombinant (His)
NOLA2,Nucleolar protein family A member 2,snoRNP protein NHP... |
Human | E. coli |
NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein particle with GAR1 (NOLA1). NHP2 is involved in a variety of aspects of rRNA processing and modification. NHP2 localizes to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies. NHP2 may also be required for correct processing or intranuclear trafficking of TERC... | |||
TMPH-01089 |
CBX7 Protein, Human, Recombinant (His)
Chromobox protein homolog 7,CBX7 |
Human | E. coli |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in hi... | |||
TMPH-01833 |
Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)
|
HPV 16 | Yeast |
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several... | |||
TMPH-01832 |
Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)
|
HPV 16 | E. coli |
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several... |