Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T82821 | BRD9 Degrader-1
化合物 BRD9 Degrader-1
|
98% |
|
|
BRD9Degrader-1为一种BRD9降解剂,表现出对BRD9微摩尔级的结合亲和力,并对BRD9与VCB形成的三元复合体具有纳摩尔级别的亲和力。 | ||||
T10520 | BET-IN-2
化合物 T10520
|
2104688-91-5 | 98% |
|
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1). | ||||
T13849 | PROTAC BET Degrader-1
化合物 T13849
|
2093386-22-0 | 98% |
|
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC. | ||||
T14512 | BAZ2-ICR
化合物 T14512
|
1665195-94-7 | 98% |
|
BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM an... | ||||
T11597 | IACS-9571
化合物 T11597
|
1800477-30-8 | 98% |
|
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). | ||||
T15443 | GSK8814
化合物 T15443
|
1997369-78-4 | 98% |
|
GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold sel... | ||||
T15397 | GNE-049
化合物 T15397
|
1936421-41-8 | 98% |
|
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, resp... | ||||
T17294 | ZL0454
化合物 T17294
|
2229042-77-5 | 98% |
|
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2). | ||||
T13835 | PROTAC BRD4 Degrader-3
化合物 T13835
|
2313234-00-1 | 98% |
|
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4. | ||||
T13785 | MZP-54
化合物 T13785
|
2010159-47-2 | 98% |
|
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2) | ||||
T12560 | PROTAC BRD9 Degrader-1
化合物 T12560
|
2097971-01-0 | 98% |
|
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM. | ||||
T11291 | FKBP12 PROTAC dTAG-13
化合物 T11291
|
2064175-41-1 | 98% |
|
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al... | ||||
T13850 | PROTAC BET degrader-3
化合物 T13850
|
T13850 | 98% |
|
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC. | ||||
T15399 | GNE-207
化合物 T15399
|
2158266-58-9 | 98% |
|
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207... | ||||
T17297 | ZXH-3-26
化合物 T17297
|
2243076-67-5 | 98% |
|
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM). | ||||
T13977 | (R)-UT-155
化合物 T13977
|
2031161-54-1 | 98% |
|
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand. | ||||
T72096 | Eleven-Nineteen-Leukemia Protein IN-1
化合物 Eleven-Nineteen-Leukemia Protein IN-1
|
2894121-68-5 | 98% |
|
Eleven-Nineteen-Leukemia Protein IN-1 为ENL YEATS域抑制剂,具有IC50 14.5 nM。该化合物通过与ENL蛋白相互作用,提升ENL蛋白的体外热稳定性。 | ||||
T72097 | Eleven-Nineteen-Leukemia Protein IN-2
化合物 Eleven-Nineteen-Leukemia Protein IN-2
|
2894121-78-7 | 98% |
|
Eleven-Nineteen-Leukemia Protein IN-2(compound 23)是用于白血病研究的ENL抑制剂,具有10.7 nM的IC50值。 | ||||
T72098 | Eleven-Nineteen-Leukemia Protein IN-3
化合物 Eleven-Nineteen-Leukemia Protein IN-3
|
2894121-83-4 | 98% |
|
Eleven-Nineteen-Leukemia Protein IN-3为口服活性ENL YEATS结构域抑制剂,IC50为15.4 nM。该化合物可通过下调细胞内MYC表达增强ENL蛋白的体外热稳定性。 | ||||
T72722 | Physachenolide C
化合物 Physachenolide C
|
791117-61-8 | 98% |
|
Physachenolide C 是一种选择性BET抑制剂,具有诱导细胞凋亡(apoptosis)和引起细胞周期在G0-G1期停滞的抗肿瘤活性。 |