MmpL3

SQ109 (NSC-722041) 是一种有效的锥鞭毛体形式的寄生虫抑制剂 (IC50 = 50 nM)。 SQ109 是一种抗结核药物，靶向 MmpL3。

AU1235是金刚烷脲，是一种MmpL3抑制剂。结核分枝杆菌蛋白MmpL3在细胞壁合成中起重要作用，它影响海藻糖单支霉菌酸酯跨内膜转运。

BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌，抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。

C-215 是MmpL3抑制剂。它在 HTS 中被鉴定为对结核分枝杆菌具有独立的甘油活性，对哺乳动物细胞的非特异性毒性较低，对结核分枝杆菌的IC90=16 μM，并且能够有效抑制在巨噬细胞中生长的结核分枝杆菌。

NITD-349 是MmpL3的抑制剂，它对毒性结核分枝杆菌 H37Rv 显示出高效的抗分枝杆菌活性，MIC50 为 23 nM。

MmpL3-IN-2为一种具备中等代谢稳定性和较低细胞毒性的MmpL3抑制剂，适用于结核病研究。

MmpL3-IN-3 (Compound 12) 为一种MmpL3抑制剂，对 H37Rv 的最小抑制浓度(MIC)为 0.1 μM。该化合物在小鼠肝微粒体中具有良好稳定性，适用于抗结核研究。

MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].

GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6.

BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).

BM635 mesylate 是一种 MmpL3 的抑制剂，表现出明显的抗分歧杆菌作用，抑制和结合分歧杆菌 H37Rv 的 MIC50值为 0.6 μM。与游离态 BM635 相比，BM635 mesylate 能够明显提高生物利用度。

BM635 hydrochloride 是一种 MmpL3 抑制剂，表现出显著的抗分歧杆菌效果，能够抑制结合分歧杆菌 H37Rv (MIC50: 0.08 μM)。与游离 BM635 相比，BM635 hydrochloride 在体内暴露量提高了一倍。

MSU-43085, an orally active MmpL3 inhibitor targeting Mycobacterium tuberculosis (Mtb), demonstrates effective inhibition of Mtb in an acute murine tuberculosis infection model. This compound is applicable in tuberculosis research [1].

BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).

IC2418 is an MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis.

BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).