JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .

Cat. No.	Product Name	CAS No.	Purity
T38665	OVA-E1 peptide TFA 化合物OVA-E1 peptide TFA	1262750-80-0
T38665	OVA-E1 peptide TFA 在突变型和野生型胸腺细胞中都能同样地激活 p38 和 JNK 级联。
TN4394	Kobophenol A 化合物 TN4394	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN4938	Samidin 化合物 TN4938	477-33-8	98%
TN4938	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
T78829	JNK2-IN-1 化合物 JNK2-IN-1		98%
T78829	JNK2-IN-1（Compound J27）是一款具有抗炎活性的JNK2抑制剂，其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的释放，从而减轻脂多糖（LPS）引起的急性肺损伤（ALI）及脓毒症症状。
T79296	JNK-IN-12 化合物 JNK-IN-12		98%
T79296	JNK-IN-12（compound P2）是一种针对线粒体的JNK抑制剂，其IC50为66.3 nM，由线粒体特异性细胞穿透肽与特异性JNK抑制剂SP600125构成。该化合物特异性作用于线粒体JNK不影响核内JNK信号，能够抑制线粒体JNK磷酸化。JNK-IN-12在体内外模型中对帕金森病的改善显示出潜在效果。
T79489	JNK-1-IN-2 化合物 JNK-1-IN-2		98%
T79489	JNK-1-IN-2（Compound c6）是一种选择性JNK-1抑制剂，其IC50值为33.5 nM。同时，该化合物对JNK-2和JNK-3也具有抑制作用，其IC50值分别为112.9 nM和33.2 nM。通过抑制c-Jun蛋白的磷酸化，JNK-1-IN-2能够逆转肺部损伤，并且可以被应用于肺纤维化的相关研究。
T79754	JNK-IN-14 化合物 JNK-IN-14		98%
T79754	JNK-IN-14是一种激酶（JNK1/2/3）抑制剂，IC50值为1.81、12.7和10.5 nM。它能诱导早期apoptosis，并在G2/M阶段引起细胞周期阻滞。与SP600125相比，在K562白血病细胞中，JNK-IN-14更强有效地抑制了Beclin-1的表达。
T80005	N-Butyl α-D-fructofuranoside 化合物 n-Butyl α-D-fructofuranoside	80971-59-1	98%
T80005	n-Butyl α-D-fructofuranoside，分离自Ulmus davidiana var. japonica的根皮，通过激活JNK促进Nrf2活性，并表现出抗炎效应。
T10937	D-JNKI-1 化合物 T10937	1445179-97-4	98%
T10937	D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.
TN4410	Lappaol C 化合物 TN4410	64855-00-1	98%
TN4410	Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also ...
TN3587	Capillarisin 化合物 TN3587	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4877	Quercetin 3,4'-dimethyl ether 化合物 TN4877	33429-83-3	98%
TN4877	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN4263	Isoangustone A 化合物 TN4263	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN4317	Isopedicin 化合物 TN4317	4431-42-9	98%
TN4317	Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN2511	Britannilactone diacetate 化合物 TN2511	1286694-67-4	98%
TN2511	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN5011	Shizukaol B 化合物 TN5011	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1775	Isocryptotanshinone 异隐丹参酮	22550-15-8	98%
TN1775	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T72714	JNK3 inhibitor-3 化合物 JNK3 inhibitor-3	2873465-25-7	98%
T72714	JNK3inhibitor-3（compound 15g）是一种选择性的c-Jun N-terminal kinase3（JNK3）抑制剂，具有良好的血脑屏障穿透性和口服生物利用度。其对JNK1、JNK2和JNK3的IC50分别为147.8 nM、44.0 nM和4.1 nM。在小鼠痴呆模型中，JNK3inhibitor...