COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product Name	CAS No.	Purity
TMA0291	Dehydroglyasperin D 化合物 TMA0291	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
T11605	(-)-Ibuprofenamide 化合物 T11605	121839-78-9	98%
T11605	(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
T13160	Timegadine 替美加定	71079-19-1	98%
T13160	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM f...
TN3726	Cudraflavone B 化合物 TN3726	19275-49-1	98%
TN3726	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN4648	Nepetoidin B 化合物Nepetoidin B	55486-06-1	98%
TN4648	Nepetoidin B 具有抗真菌、抗细菌和抗炎作用，它可以抑制 LPS 刺激的 NO 生成，可能是通过调节 RAW 264.7 细胞中由 MKP-5/NF-ÎºB 通路介导的 iNOS 。
TN4307	Isolimonexic acid 化合物 TN4307	73904-93-5	98%
TN4307	Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
TN5264	Xanthoxyletin 化合物 TN5264	84-99-1	98%
TN5264	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
TN2641	15-Methoxypinusolidic acid 化合物 TN2641	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN1407	Artocarpin 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮	7608-44-8	98%
TN1407	Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
TN5093	Taiwanhomoflavone A 化合物 TN5093	265120-00-1	98%
TN5093	Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colo...
TN5130	Tetrahydroamentoflavone 穗花杉双黄酮	48236-96-0	98%
TN5130	Tetrahydroamentoflavone 是一种有效的 XO 抑制剂（IC50 = 92 nM，Ki = 982 nM），具有抗炎作用。Tetrahydroamentoflavone 可用于炎症和痛风的研究。
TN1581	Dihydroguaiaretic acid 化合物Dihydroguaiaretic acid	66322-34-7	98%
TN1581	Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
TN4013	Esculentic acid 化合物 TN4013	103974-74-9	98%
TN4013	Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
TN3806	Dehydroglyasperin C 化合物 TN3806	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN4659	Nimbin 宁宾	5945-86-8	98%
TN4659	Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbi...
TN4635	Neoechinulin A 化合物 TN4635	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
T0824	4-Nonylphenol polyethoxylate 壬苯醇醚	26027-38-3	polymer
T0824	4-Nonylphenol polyethoxylate (Nonoxinol-9) 是一种表面活性剂，普遍用作避孕药中的杀精剂。
T0065	Acetaminophen 对乙酰氨基酚	103-90-2	99.99%
T0065	Acetaminophen (APAP) 是一种 COX 抑制剂，抑制 COX-1 和 COX-2 (IC50=113.7/25.8 μM)。Acetaminophen 具有解热镇痛活性，以及较弱的抗炎活性。
T0196	Diclofenac 双氯芬酸	15307-86-5	99.99%
T0196	Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物，是 COX 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM，0.84 μM。它通过活化 caspa...
T11005	Desmethyl Celecoxib 塞来昔布杂质3	170569-87-6	99.98%
T11005	Desmethyl Celecoxib 是一种选择性的环氧化酶 2 (COX-2) 抑制剂，IC50为 32 nM，具有抗炎活性。