CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product Name	CAS No.	Purity
T10172	5-Iodo-indirubin-3'-monoxime 5-碘靛红-3'-单肟	331467-03-9	98%
T10172	5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂，IC50值分别为 9、20 和 25 nM，与 ATP 竞争性地结合酶的催化位点。
T13309	Voruciclib hydrochloride 化合物 T13309	1000023-05-1	98%
T13309	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T72507	Palbociclib orotate 化合物 Palbociclib orotate	2757498-64-7	98%
T72507	Palbociclib (PD 0332991) orotate 是一种口服活性的CDK4和CDK6选择性抑制剂，其IC50值分别为11 nM和16 nM。该化合物对癌细胞展示出抗增殖效果，并促使细胞周期处于阻滞状态。该药物适用于HR阳性、HER2阴性乳腺癌以及肝细胞癌的研究。
T74852	PROTAC CDK9 degrader-6 化合物 PROTAC CDK9 degrader-6	2935587-91-8	98%
T74852	PROTACCDK9 degrader-6 是靶向CDK9的特异性PROTAC分子，能通过蛋白酶体介导的机制实现CDK9的降解。该化合物针对CDK942与CDK955异构体的DC50分别为0.03 μM和0.05 μM。
T2082	CDK4-IN-1 化合物CDK4-IN-1	1256963-02-6	98%
T2082	CDK4-IN-1 是一种新型的特异性 CDK4/Cyclin D1 抑制剂，IC50 为 10 nM；分别是 CDK1/Cyclin B (IC50>15 uM) 和 CDK2/Cyclin A (IC50=5.265 uM) 的 1500 倍和 500 倍。
T13627	CP-10 化合物 T13627	2366268-80-4	98%
T13627	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
T10724	Cdc7-IN-1 化合物 T10724	1402055-25-7	98%
T10724	Cdc7-IN-1 is a highly selective and ATP competitive inhibitor of Cdc7 kinase (IC50: 0.6 nM at 1 mM ATP). It potently inhibits Cdc7 activity in cancer cells and e...
T67780	AM5992 化合物AM5992	1169694-98-7	98%
T67780	AM5992 (化合物195) 是有效的CDK4和CDK6抑制剂（CDK4，IC50=0.013μM）。AM5992可用于CDK4介导的疾病的研究。
TN4411	Lappaol F 化合物 TN4411	69394-17-8	98%
TN4411	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. 2. Lap...
TN3719	Cristacarpin 化合物 TN3719	74515-47-2	98%
TN3719	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
T11345	Lerociclib 化合物 T11345	1628256-23-4	98%
T11345	Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
T11632	IIIM-290 化合物 T11632	2213468-64-3	98%
T11632	IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).
T10747	CDK9-IN-9 化合物 T10747	2246956-84-1	98%
T10747	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).
T12552	PROTAC CDK2/9 Degrader-1 化合物 T12552	2408641-24-5	98%
T12552	PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
T10741	CDK9-IN-1 化合物 T10741	1415559-43-1	98%
T10741	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
T14136	AG-024322 化合物 T14136	837364-57-5	98%
T14136	AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
T10743	CDK9-IN-11 化合物 T10743	2748368-15-0	98%
T10743	CDK9-IN-11 是一种有效的CDK9抑制剂，可作为 PROTAC CDK9 Degrader-1 的配体。
TN3247	7-O-Prenylscopoletin 化合物 TN3247	13544-37-1	98%
TN3247	7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
T14990	CDK12-IN-3 化合物 T14990	2220184-50-7	98%
T14990	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).